Sabichi A L, Birrer M J
Div of Cancer Prevention and Control, National Cancer Institute, Bethesda.
Oncology (Williston Park). 1993 Jun;7(6):19-26; discussion 31-2, 37.
With the overall incidence of lung cancer increasing and little progress being made in effective treatment, new approaches to this disease, such as early detection and prevention, are desperately needed. Rapid advances in molecular oncology over the past decade have provided us with new insights into the pathogenesis of lung cancer. Characterization of molecular changes in growth-regulating genes in lung cancer cells has been a first step toward identification of molecular markers of early lung cancer. In addition, we have made great strides in our understanding of the process of tumor promotion in lung cancer by the identification of specific substances as tumor promoters and the biochemical pathways by which they function. These insights will provide us with a beginning for the development of screening assays, early detection tests, and chemopreventive agents, hopefully allowing us to make an impact on lung cancer mortality.
随着肺癌总体发病率的上升以及有效治疗进展甚微，迫切需要针对这种疾病的新方法，如早期检测和预防。过去十年分子肿瘤学的快速发展为我们提供了对肺癌发病机制的新认识。对肺癌细胞中生长调节基因分子变化的表征是识别早期肺癌分子标志物的第一步。此外，通过鉴定特定物质作为肿瘤促进剂及其发挥作用的生化途径，我们在理解肺癌肿瘤促进过程方面取得了巨大进展。这些见解将为我们开发筛查试验、早期检测测试和化学预防剂提供一个开端，有望使我们对肺癌死亡率产生影响。
