Carbone D P
Department of Medicine, Vanderbilt Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232-9450, USA.
Semin Oncol. 1997 Aug;24(4):388-401.
Lung cancer is the most common cause of cancer death in the United States among both men and women, with an estimated 177,000 new cases and 159,000 deaths in 1996. Its overall incidence is increasing, particularly in women, and despite many complex and aggressive approaches to therapy, and great strides in understanding its biology and etiology, corresponding improvements in outcome are not yet apparent. This article will summarize the state of knowledge of the biology and genetics of lung cancer. These and future advances in our knowledge will certainly provide the foundation for future advances in therapeutics.
肺癌是美国男性和女性癌症死亡的最常见原因，1996年估计有17.7万新发病例和15.9万例死亡。其总体发病率正在上升，尤其是在女性中，尽管有许多复杂且积极的治疗方法，并且在了解其生物学和病因方面取得了巨大进展，但相应的治疗效果改善尚不明显。本文将总结肺癌生物学和遗传学的知识现状。这些以及我们知识的未来进展必将为治疗学的未来进展奠定基础。
