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1

Endogenous cortisol exerts antiemetic effect similar to that of exogenous corticosteroids.内源性皮质醇发挥的止吐作用与外源性皮质类固醇相似。

Br J Cancer. 1993 Jul;68(1):112-4. doi: 10.1038/bjc.1993.295.

2

Single high-dose dexamethasone improves the effect of ondansetron on acute chemotherapy-induced nausea and vomiting but impairs the control of delayed symptoms.单次大剂量地塞米松可提高昂丹司琼对急性化疗引起的恶心和呕吐的疗效，但会削弱对延迟症状的控制。

Support Care Cancer. 1996 Nov;4(6):440-6. doi: 10.1007/BF01880642.

3

Effects of ondansetron on chemotherapy-induced acute and delayed emesis--a pilot study.昂丹司琼对化疗引起的急性和迟发性呕吐的影响——一项初步研究。

Acta Oncol. 1991;30(5):649-51. doi: 10.3109/02841869109092434.

4

Ondansetron plus dexamethasone versus metoclopramide plus dexamethasone plus diphenhydramine in cisplatin-treated patients with ovarian cancer. Italian Group for Antiemetic Research.昂丹司琼联合地塞米松与甲氧氯普胺联合地塞米松及苯海拉明用于顺铂治疗的卵巢癌患者。意大利止吐研究组。

Support Care Cancer. 1994 May;2(3):167-70.

5

[Efficacy of ondansetron in acute and delayed cisplatin-induced nausea and vomiting].昂丹司琼对顺铂所致急性和迟发性恶心呕吐的疗效

Bull Cancer. 1996 Feb;83(2):147-53.

6

The antiemetic efficacy of oral ondansetron plus intravenous dexamethasone in patients with gynecologic malignancies receiving carboplatin-based chemotherapy.口服昂丹司琼联合静脉注射地塞米松对接受以卡铂为基础化疗的妇科恶性肿瘤患者的止吐疗效。

Gynecol Oncol. 2000 Jul;78(1):43-6. doi: 10.1006/gyno.2000.5824.

7

Comparable safety and antiemetic efficacy of a brief (30-second bolus) intravenous granisetron infusion and a standard (15-minute) intravenous ondansetron infusion in breast cancer patients receiving moderately emetogenic chemotherapy.在接受中度致吐性化疗的乳腺癌患者中，短暂（30秒推注）静脉注射格拉司琼与标准（15分钟）静脉注射昂丹司琼的安全性和止吐疗效相当。

Cancer J Sci Am. 1998 Jan-Feb;4(1):52-8.

8

Comparison of ondansetron-dexamethasone-lorazepam versus metoclopramide-dexamethasone-lorazepam in the control of cisplatin induced emesis.昂丹司琼-地塞米松-劳拉西泮与甲氧氯普胺-地塞米松-劳拉西泮在控制顺铂所致呕吐方面的比较。

J Med Assoc Thai. 2001 Jul;84(7):966-72.

9

Antiemetic effect of ondansetron and dexamethasone in gynecologic malignant patients receiving chemotherapy.昂丹司琼和地塞米松对接受化疗的妇科恶性肿瘤患者的止吐作用。

J Med Assoc Thai. 2006 Oct;89 Suppl 4:S29-36.

10

Ondansetron and dexamethasone versus standard combination antiemetic therapy. A randomized trial for the prevention of acute and delayed emesis induced by cyclophosphamide-doxorubicin chemotherapy and maintenance of antiemetic effect at subsequent courses.昂丹司琼与地塞米松对比标准联合止吐疗法：一项预防环磷酰胺-阿霉素化疗引起的急性和迟发性呕吐以及在后续疗程维持止吐效果的随机试验。

Am J Clin Oncol. 1994 Dec;17(6):522-6.

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Corticosteroids for adult patients with advanced cancer who have nausea and vomiting (not related to chemotherapy, radiotherapy, or surgery).用于患有恶心和呕吐（与化疗、放疗或手术无关）的晚期癌症成年患者的皮质类固醇。

Cochrane Database Syst Rev. 2017 Jul 3;7(7):CD012002. doi: 10.1002/14651858.CD012002.pub2.

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Glucocorticoid resistance of migration and gene expression in a daughter MDA-MB-231 breast tumour cell line selected for high metastatic potential.高转移潜能 MDA-MB-231 乳腺癌细胞系中迁移和基因表达的糖皮质激素抵抗。

Sci Rep. 2017 Mar 6;7:43774. doi: 10.1038/srep43774.

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Glucocorticoids and Cancer.糖皮质激素与癌症

Adv Exp Med Biol. 2015;872:315-33. doi: 10.1007/978-1-4939-2895-8_14.

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Visually induced nausea causes characteristic changes in cerebral, autonomic and endocrine function in humans.视觉诱发的恶心会导致人类大脑、自主神经系统和内分泌功能发生特征性变化。

J Physiol. 2015 Mar 1;593(5):1183-96. doi: 10.1113/jphysiol.2014.284240. Epub 2015 Jan 29.

5

Palonosetron plus single-dose dexamethasone for the prevention of nausea and vomiting in women receiving anthracycline/cyclophosphamide-containing chemotherapy: meta-analysis of individual patient data examining the effect of age on outcome in two phase III trials.帕洛诺司琼联合地塞米松预防接受含蒽环类药物/环磷酰胺化疗的女性恶心和呕吐：两项 III 期临床试验中个体患者数据的荟萃分析，评估年龄对结局的影响。

Support Care Cancer. 2013 Feb;21(2):565-73. doi: 10.1007/s00520-012-1558-9. Epub 2012 Aug 8.

6

Signals for nausea and emesis: Implications for models of upper gastrointestinal diseases.恶心和呕吐信号：对上消化道疾病模型的启示

Auton Neurosci. 2006 Apr 30;125(1-2):100-15. doi: 10.1016/j.autneu.2006.01.008. Epub 2006 Mar 23.

7

Role of dexamethasone dosage in combination with 5-HT3 antagonists for prophylaxis of acute chemotherapy-induced nausea and vomiting.地塞米松剂量联合5-羟色胺3受体拮抗剂在预防急性化疗所致恶心和呕吐中的作用

Br J Cancer. 1999 Feb;79(3-4):637-9. doi: 10.1038/sj.bjc.6690100.

8

Single high-dose dexamethasone improves the effect of ondansetron on acute chemotherapy-induced nausea and vomiting but impairs the control of delayed symptoms.单次大剂量地塞米松可提高昂丹司琼对急性化疗引起的恶心和呕吐的疗效，但会削弱对延迟症状的控制。

Support Care Cancer. 1996 Nov;4(6):440-6. doi: 10.1007/BF01880642.

9

Impact of tumour burden on chemotherapy-induced nausea and vomiting.肿瘤负荷对化疗所致恶心和呕吐的影响。

Br J Cancer. 1996 Oct;74(7):1114-9. doi: 10.1038/bjc.1996.499.

10

An interaction of ondansetron and dexamethasone antagonizing cisplatin-induced acute and delayed emesis in the ferret.昂丹司琼与地塞米松相互作用拮抗雪貂顺铂诱导的急性和迟发性呕吐。

Br J Pharmacol. 1996 May;118(2):209-14. doi: 10.1111/j.1476-5381.1996.tb15388.x.

本文引用的文献

1

Mechanism of decline in rat brain 5-hydroxytryptamine after induction of liver tryptophan pyrrolase by hydrocortisone: roles of tryptophan catabolism and kynurenine synthesis.氢化可的松诱导肝脏色氨酸吡咯酶后大鼠脑内5-羟色胺水平下降的机制：色氨酸分解代谢和犬尿氨酸合成的作用

Br J Pharmacol. 1981 Nov;74(3):695-700. doi: 10.1111/j.1476-5381.1981.tb10480.x.

2

Antiemetic efficacy of dexamethasone therapy in patients receiving cancer chemotherapy.地塞米松治疗对接受癌症化疗患者的止吐疗效。

Arch Intern Med. 1983 Jul;143(7):1347-9.

3

Estimation of a common effect parameter from sparse follow-up data.从稀疏随访数据中估计共同效应参数。

Biometrics. 1985 Mar;41(1):55-68.

4

Acute changes in blood-CSF barrier permselectivity to serum proteins after intrathecal methotrexate and CNS irradiation.鞘内注射甲氨蝶呤和中枢神经系统照射后血脑脊液屏障对血清蛋白的通透选择性急性变化。

J Neurol. 1985;231(6):336-9. doi: 10.1007/BF00313712.

5

Controlling delayed vomiting: double-blind, randomized trial comparing placebo, dexamethasone alone, and metoclopramide plus dexamethasone in patients receiving cisplatin.

J Clin Oncol. 1989 Jan;7(1):108-14. doi: 10.1200/JCO.1989.7.1.108.

6

Influence of dexamethasone dose on the control of chemotherapy-induced nausea and vomiting.地塞米松剂量对化疗所致恶心和呕吐控制的影响。

Eur J Cancer. 1991;27(8):1062-3. doi: 10.1016/0277-5379(91)90286-m.

7

The current role of anti-emetic drugs in oncology: a recent revolution in patient symptom control.止吐药物在肿瘤学中的当前作用：患者症状控制方面的近期变革。

Cancer Treat Rev. 1991 Jun;18(2):95-135. doi: 10.1016/0305-7372(91)90009-o.

8

Comparison of ondansetron and ondansetron plus dexamethasone as antiemetic prophylaxis during cisplatin-containing chemotherapy.昂丹司琼与昂丹司琼联合地塞米松在含顺铂化疗中作为预防性止吐药的比较。

Lancet. 1991 Aug 24;338(8765):487-90. doi: 10.1016/0140-6736(91)90555-4.

9

Nausea in cancer chemotherapy is inversely related to urinary cortisol excretion.癌症化疗中的恶心与尿皮质醇排泄呈负相关。

Br J Cancer. 1992 May;65(5):779-80. doi: 10.1038/bjc.1992.165.

内源性皮质醇发挥的止吐作用与外源性皮质类固醇相似。

Endogenous cortisol exerts antiemetic effect similar to that of exogenous corticosteroids.

作者信息

Hursti T J, Fredrikson M, Steineck G, Börjeson S, Fürst C J, Peterson C

机构信息

Department of Psychiatry and Psychology, Karolinska Institute, Stockholm, Sweden.

出版信息

Br J Cancer. 1993 Jul;68(1):112-4. doi: 10.1038/bjc.1993.295.

DOI:10.1038/bjc.1993.295

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1968293/

Abstract

Lower pre-chemotherapy night time cortisol excretion predicted more severe cisplatin induced nausea and vomiting in 42 ovarian cancer patients receiving ondansetron as a single antiemetic agent. Dexamethasone administration added to the antiemetic effect of ondansetron principally in patients who had low excretion of cortisol.

摘要

在42例接受昂丹司琼作为单一止吐药的卵巢癌患者中，化疗前夜间皮质醇排泄量较低预示着顺铂诱导的恶心和呕吐更为严重。地塞米松的使用主要在皮质醇排泄量低的患者中增强了昂丹司琼的止吐效果。