Comstock G W, Gordon G B, Hsing A W
Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205.
Cancer Epidemiol Biomarkers Prev. 1993 May-Jun;2(3):219-21.
Levels of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) in sera collected and frozen in 1974 were studied among 81 prostate cancer cases diagnosed in the following 12 years and 81 age- and race-matched controls. Although mean levels of DHEA were 11% lower among cases than controls and DHEA-S levels were 12% lower than among controls, no dose-response association was noted for either DHEA or DHEA-S. It seems unlikely that serum levels of DHEA or DHEA-S are important risk factors for prostate cancer.
对1974年采集并冷冻的血清中的脱氢表雄酮（DHEA）和硫酸脱氢表雄酮（DHEA-S）水平进行了研究，研究对象为接下来12年中确诊的81例前列腺癌病例以及81例年龄和种族匹配的对照。尽管病例组中DHEA的平均水平比对照组低11%，DHEA-S水平比对照组低12%，但未发现DHEA或DHEA-S存在剂量反应关联。DHEA或DHEA-S的血清水平似乎不太可能是前列腺癌的重要危险因素。
