Dar M S, Li C, Bowman E R
Department of Pharmacology, School of Medicine, East Carolina University, Greenville, NC 27858.
Brain Res Bull. 1993;32(1):23-8. doi: 10.1016/0361-9230(93)90314-2.
A high correlation between alcohol use and smoking has long been suggested by epidemiological data. We examined the potential behavioral interactions between ethanol and nicotine using ethanol-induced motor incoordination as the test response in mice. Effect of pretreatment of various doses of (-)-nicotine, (-)-cotinine, a major metabolite of nicotine, and (+)-nicotine administered ICV on ethanol (IP)-induced motor incoordination was investigated. (-)-Nicotine (0.19, 0.38, 0.77 and, 1.54 nmoles ICV) produced significant attenuation of motor incoordination due to ethanol (2 g/kg IP) in a nearly dose-related manner which was blocked by ICV hexamethonium and trimethaphan, both purported nicotinic antagonists. (-)-Cotinine (0.35, 0.70, 1.41 nmole ICV) produced similar attenuation but was les potent than (-)-nicotine. Attenuation by (+)-nicotine (0.19, 0.38, and 0.77 nmoles ICV) was also significant but only at 0.77 nmole dose level. (+)-Nicotine-induced attenuation of motor incoordination by ethanol was antagonized by nicotinic antagonists. Data obtained suggest a central behavioral interaction between ethanol and nicotine at least through the participation of cholinergic nicotinic receptors.
长期以来，流行病学数据一直表明酒精使用与吸烟之间存在高度相关性。我们以乙醇诱导的运动不协调作为小鼠的测试反应，研究了乙醇与尼古丁之间潜在的行为相互作用。研究了脑室内注射不同剂量的（-）-尼古丁、尼古丁的主要代谢产物（-）-可替宁和（+）-尼古丁预处理对乙醇（腹腔注射）诱导的运动不协调的影响。（-）-尼古丁（0.19、0.38、0.77和1.54纳摩尔，脑室内注射）以近剂量相关的方式显著减轻了乙醇（2克/千克，腹腔注射）引起的运动不协调，而这被脑室内注射的六甲铵和阿方那特阻断，这两种药物均为所谓的烟碱拮抗剂。（-）-可替宁（0.35、0.70、1.41纳摩尔，脑室内注射）产生了类似的减轻作用，但效力低于（-）-尼古丁。（+）-尼古丁（0.19、0.38和0.77纳摩尔，脑室内注射）引起的减轻作用也很显著，但仅在0.77纳摩尔剂量水平。烟碱拮抗剂可拮抗（+）-尼古丁诱导的乙醇所致运动不协调的减轻作用。所获得的数据表明，乙醇和尼古丁之间至少通过胆碱能烟碱受体的参与存在中枢行为相互作用。
