Masood S, Rhatigan R M, Wilkinson E W, Barwick K W, Wilson W J
University of Florida Health Science Center, Department of Pathology, Jacksonville 32209-6511.
Cancer. 1993 Jul 15;72(2):511-8. doi: 10.1002/1097-0142(19930715)72:2<511::aid-cncr2820720230>3.0.co;2-q.
Adenocarcinoma of the uterine cervix typically is an aggressive neoplasm with a propensity for early invasion and dissemination. Little data are available correlating histologic, histochemical, or immunocytochemical parameters with the biologic behavior of this neoplasm. Specifically, the implication of expression of estrogen and progesterone receptors in cervical adenocarcinoma is essentially undefined.
An immunocytochemical hormone receptor assay using specific monoclonal antibodies against estrogen receptors (ER) and progesterone receptors (PgR) was used to study paraffin-embedded specimens from 54 patients with primary cervical adenocarcinomas. The specimens were evaluated for heterogeneity and intensity of staining. An attempt also was made to study the relationship between the pattern of hormone receptor expression and other established prognostic indicators.
In all patients, diffuse positive staining of benign endocervical epithelial or stromal cells was observed. Positive immunostaining was seen in the adenocarcinoma specimens of 16 of 54 (30%) patients for ER and 19 of 54 (35%) patients for PgR. Expression of ER and PgR statistically correlated with each other (P = 0.0001). Endocervical-type adenocarcinoma had the highest degree of staining for both ER and PgR. Clear cell carcinomas and intestinal-type carcinomas were negative for both receptors. Positivity for ER and PgR inversely correlated with histologic grade as defined by the International Federation of Gynecology and Obstetrics (FIGO). The relationship between hormone receptor expression and FIGO stage was not statistically significant. Survival was associated with clinical stage (P = 0.004) and with immunocytochemical status of ER expression (P = 0.032) and PgR expression (P = 0.009).
This study of 54 specimens from patients with cervical adenocarcinoma suggests that positive expression of ER and PgR is associated with prolonged survival.
子宫颈腺癌通常是一种侵袭性肿瘤，易于早期侵袭和扩散。关于组织学、组织化学或免疫细胞化学参数与该肿瘤生物学行为之间相关性的数据很少。具体而言，雌激素和孕激素受体在宫颈腺癌中的表达意义基本未明。
采用针对雌激素受体（ER）和孕激素受体（PgR）的特异性单克隆抗体进行免疫细胞化学激素受体检测，以研究54例原发性宫颈腺癌患者的石蜡包埋标本。对标本的染色异质性和强度进行评估。还尝试研究激素受体表达模式与其他既定预后指标之间的关系。
在所有患者中，均观察到宫颈管内良性上皮或基质细胞弥漫性阳性染色。54例患者中有16例（30%）的腺癌标本ER呈阳性免疫染色，54例患者中有19例（35%）的腺癌标本PgR呈阳性免疫染色。ER和PgR的表达在统计学上相互关联（P = 0.0001）。宫颈管内型腺癌的ER和PgR染色程度最高。透明细胞癌和肠型癌两种受体均为阴性。ER和PgR阳性与国际妇产科联合会（FIGO）定义的组织学分级呈负相关。激素受体表达与FIGO分期之间的关系无统计学意义。生存率与临床分期（P = 0.004）以及ER表达（P = 0.032）和PgR表达（P = 0.009）的免疫细胞化学状态相关。
这项对54例宫颈腺癌患者标本的研究表明，ER和PgR的阳性表达与生存期延长相关。
