Torres G, Berná L, Estorch M, Juárez C, Martínez-Duncker D, Carrió I
Department of Nuclear Medicine, Hospital de Sant Pau, Barcelona, Spain.
Clin Nucl Med. 1993 Jun;18(6):477-81. doi: 10.1097/00003072-199306000-00003.
Radiolabeled monoclonal antibodies (MoAb) are useful in radionuclide imaging. Human anti-murine antibodies (HAMA), however, could produce immunologic effects or alter the outcome of immunoscintigraphy. Three patients are reported who had been exposed previously to radiolabeled MoAbs and in whom subsequent immunoscintigraphy was performed. All patients showed abnormal biodistribution of the antibody and increased hepatic uptake. Human anti-murine antibody was demonstrated in all patients. These results indicate that immune complexes are formed after HAMA-MoAb reaction and are then phagocytosed by cells of the reticuloendothelial system.
放射性标记单克隆抗体（MoAb）在放射性核素成像中很有用。然而，人抗鼠抗体（HAMA）可能会产生免疫效应或改变免疫闪烁显像的结果。本文报告了3例曾接触过放射性标记MoAb且随后进行了免疫闪烁显像的患者。所有患者均显示抗体生物分布异常及肝脏摄取增加。所有患者均检测出了人抗鼠抗体。这些结果表明，HAMA与MoAb反应后形成免疫复合物，然后被网状内皮系统细胞吞噬。
