用99m锝标记的单克隆抗癌胚抗原抗体BW 431/26进行的免疫闪烁显像随访研究
[Immunoscintigraphic follow-up studies with the 99m-Tc marked monoclonal anti-CEA antibody BW 431/26].
作者信息
Fritzsche H
机构信息
Nuklearmedizinischen Abteilung des Landeskrankenhauses Feldkirch.
出版信息
Acta Med Austriaca. 1990;17(2-3):44-6.
PMID:2220267
Abstract
Repeated immunoscintigraphy with murine monoclonal antibodies was performed in only few patients because of developing HAMA (Human Anti Mouse Antibodies) and therefore high risk of allergic reactions. Patients with HAMA, which could be observed in about 26% after immunoscintigraphy, show high liver-spleen uptake of labeled monoclonal antibodies in further examinations in some cases.
摘要
由于会产生人抗鼠抗体（HAMA），进而存在高过敏反应风险，仅有少数患者接受了鼠单克隆抗体的重复免疫闪烁扫描检查。在免疫闪烁扫描后约26%的患者中可观察到HAMA，在后续检查中，部分此类患者显示标记的单克隆抗体在肝脏和脾脏有较高摄取。
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