Franco A, Hampton W R, Greenspan B S, Holm A L, O'Mara R E
Department of Radiology, University of Rochester Medical Center, New York.
Clin Nucl Med. 1993 Jun;18(6):510-1. doi: 10.1097/00003072-199306000-00011.
The side effects of prolonged isotretinoin therapy include progressive calcification of ligamentous and tendon insertions, premature fusion of epiphyses, and modeling abnormalities of long bones. Increased calcification of gastric mucosa has been reported only in animal studies, but not in humans. A case of a child who was treated with isotretinoin for 26 months for a dermatologic disorder and who showed abnormal gastric uptake of 99m-Tc MDP on a bone scan is reported.
长期异维甲酸治疗的副作用包括韧带和肌腱附着处的进行性钙化、骨骺过早融合以及长骨塑形异常。仅在动物研究中报道过胃黏膜钙化增加，而在人类中未发现。本文报告了一例因皮肤病用异维甲酸治疗26个月的儿童，其骨扫描显示99m锝亚甲基二膦酸盐（99m-Tc MDP）胃摄取异常。
