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实验性脂肪栓塞:肺脂肪处理特征的动态评估

Experimental fat embolism: a dynamic assessment of pulmonary fat-handling characteristics.

作者信息

Sikorski J M, Pardy B J, Dudley H A

出版信息

Br J Surg. 1977 Jan;64(1):11-4. doi: 10.1002/bjs.1800640104.

DOI:10.1002/bjs.1800640104
PMID:831949
Abstract

Injection 125I-glyceryl trioleate (0-5 mg/kg) into the right atrium of anaesthetized greyhounds caused the following changes: sequestration of far in the right side of the heart; 95 per cent removal by the lungs in a single passage through the pulmonary circulation; subsequent release of fat into the systemic circulation; rapid overall turnover of fat trapped in the lungs and slow removal of recirculating fat by other tissues. We believe that if there is release of unemulsified fat into the circulation in traumatic fat embolism these findings are of significance in interpreting the subsequent pulmonary events.

摘要

将125I-甘油三油酸酯(0 - 5毫克/千克)注入麻醉的灵缇犬右心房会引起以下变化:大量物质滞留于心脏右侧;单次通过肺循环时,肺部清除率达95%;随后脂肪释放进入体循环;滞留在肺部的脂肪整体周转迅速,而其他组织对再循环脂肪的清除缓慢。我们认为,在创伤性脂肪栓塞中若有未乳化脂肪释放入循环,这些发现对于解释随后的肺部事件具有重要意义。

相似文献

1
Experimental fat embolism: a dynamic assessment of pulmonary fat-handling characteristics.实验性脂肪栓塞:肺脂肪处理特征的动态评估
Br J Surg. 1977 Jan;64(1):11-4. doi: 10.1002/bjs.1800640104.
2
The pathophysiological changes of experimental fat embolism: early pre-hypoxaemic changes.实验性脂肪栓塞的病理生理变化:低氧血症前期早期变化。
Br J Surg. 1977 Jan;64(1):6-10. doi: 10.1002/bjs.1800640103.
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Effects and distribution of acute fat embolism in spontaneously breathing dogs using radioactive carbon triolein.
Surg Gynecol Obstet. 1975 Sep;141(3):387-93.
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The role of free fatty acids in pulmonary fat embolism.
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The syndrome of fat embolism and its origin.脂肪栓塞综合征及其成因。
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Experimental fat embolism. Initial distribution of fat emboli labeled with 131-I in normotensive and hypotensive rabbits.实验性脂肪栓塞。正常血压和低血压兔中用131-I标记的脂肪栓子的初始分布。
Arch Pathol. 1969 Aug;88(2):171-4.
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Fat embolism syndrome: A comparison of hematologic coagulation and lipid changes in two animal models.脂肪栓塞综合征:两种动物模型中血液凝固和脂质变化的比较
Clin Orthop Relat Res. 1976 May(116):240-7.
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Pulmonary neutral fat embolism in dogs.犬的肺中性脂肪栓塞
Am J Pathol. 1979 Apr;95(1):29-42.
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Pulmonary epithelial permeability is immediately increased after embolisation with oleic acid but not with neutral fat.用油酸栓塞后肺上皮通透性立即增加,但用中性脂肪栓塞则不会。
Thorax. 1982 Mar;37(3):169-74. doi: 10.1136/thx.37.3.169.
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[Significance of pressure relations in the minor circulation for the filtration function of the lung in fat embolism].[脂肪栓塞中小循环压力关系对肺滤过功能的意义]
Bruns Beitr Klin Chir (1971). 1970 Sep;218(3):274-6.

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