Sikorski J, Pardy B J, Bradfield J W, Dudley H A
Br J Surg. 1977 Jan;64(1):6-10. doi: 10.1002/bjs.1800640103.
Glyceryl trioleate has been injected into greyhounds as a model of the fat embolism syndrome. Pulmonary vascular pressures, systemic arterial pressure and cardiac output were determined at regular intervals over an 8-hour period. It has been shown that glyceryl tioleate causes an increased pulmonary vascular resistance and a fall in cardiac output. These effects are mediated partly by a direct mechanical block of pulmonary vessels and partly through a thrombogenic property of the injected fat. The relevance of these findings to the clinical situation is discussed and a sequence of events for the fat embolism syndrome is proposed.
已将三油酸甘油酯注入灵缇犬体内作为脂肪栓塞综合征的模型。在8小时内定期测定肺血管压力、体动脉压力和心输出量。结果表明，三油酸甘油酯会导致肺血管阻力增加和心输出量下降。这些效应部分是由肺血管的直接机械阻塞介导的，部分是通过注入脂肪的血栓形成特性介导的。讨论了这些发现与临床情况的相关性，并提出了脂肪栓塞综合征的一系列事件。
