Goldstein P, McCann-Hargrove E, Magnano L
Department of Biological Sciences, University of Texas, El Paso 79968.
Cytobios. 1993;73(293):121-33.
Expected benefits, i.e. increasing life span and vitality, from ingesting d,1-alpha tocopherol (vitamin E), are not realized using vitamin E acetate (VEA) since the acetate form is only slowly converted to vitamin E in either mammalian or nematode tissues. The resultant accumulation of VEA in the cytosol is toxic, which results in aberrations in nuclear morphology, decreased life span and production of progeny, increased mean reproductive day and general loss of vitality. Incorporation of VEA into membranes results in allosteric changes in membrane structure. Such changes are proportional to increasing concentrations of VEA, thereby inhibiting the attachment of the telomere to the nuclear envelope. Reproductive and chromosomal strategies are compromised such that synaptonemal complexes, normally found during pachytene in oocytes, are rarely present in those nematodes exposed to high concentrations of VEA. The resultant loss of SCs correlates with decreased progeny and the chromosomal aberrations characteristic of hypervitaminosis E.
摄入消旋-α-生育酚（维生素E）所期望的益处，即延长寿命和增强活力，在使用维生素E醋酸酯（VEA）时无法实现，因为醋酸酯形式在哺乳动物或线虫组织中仅缓慢转化为维生素E。VEA在细胞质中的累积是有毒的，这会导致核形态异常、寿命缩短、后代数量减少、平均繁殖天数增加以及活力普遍丧失。VEA掺入膜中会导致膜结构的变构变化。这种变化与VEA浓度的增加成正比，从而抑制端粒与核膜的附着。生殖和染色体策略受到损害，以至于通常在卵母细胞粗线期发现的联会复合体，在暴露于高浓度VEA的线虫中很少出现。联会复合体的最终丧失与后代数量减少以及维生素E过多症特有的染色体畸变相关。
