Goldstein P, Raphael D, Ruiloba M C
Department of Biological Sciences, University of Texas at El Paso, 79968, USA.
Cytobios. 2001;104(405):7-23.
Spermatogenesis is inhibited in Balb/C mice as a result of oxyradical insult. However, mammalian spermatocytes and synaptonemal complexes retain their structure and function after oxyradical insult due to protection afforded by the antioxidant vitamin E. Control groups were compared with experimental groups which were fed various vitamin E-deficient diets and subjected to varying times in an humidified 100% oxygen (hyperoxia) chamber. Measurements were made of sex body volume (SBV), nuclear envelope aberrations (NEA), and synaptonemal complex structure in spermatocytes during pachytene of meiosis prophase I. Changes in the volume of the sex body were positively correlated with increased oxyradical insult. The structure of the synaptonemal complex was not altered in any of the experimental groups which is a significant observation. It is suggested that vitamin E affords antioxidant protection and inhibits the alteration of membranes and sex chromosomes in mice during meiosis.
由于氧自由基损伤，Balb/C小鼠的精子发生受到抑制。然而，由于抗氧化剂维生素E提供的保护，哺乳动物的精母细胞和联会复合体在氧自由基损伤后仍保持其结构和功能。将对照组与实验组进行比较，实验组喂食各种维生素E缺乏的饮食，并在湿度为100%的氧气（高氧）舱中暴露不同时间。在减数分裂前期I的粗线期，对精母细胞中的性体体积（SBV）、核膜畸变（NEA）和联会复合体结构进行了测量。性体体积的变化与氧自由基损伤的增加呈正相关。在任何实验组中，联会复合体的结构都没有改变，这是一个重要的观察结果。有人提出，维生素E提供抗氧化保护，并抑制小鼠减数分裂过程中膜和性染色体的改变。
