Markowska-Daniel I, Pejsak Z, Szmigielski S, Jeljaszewicz J, Pulverer G
Department of Swine Diseases, National Institute of Veterinary Research, Pulawy, Poland.
Dtsch Tierarztl Wochenschr. 1993 May;100(5):185-8.
The potent immunomodifier Propionibacterium avidum KP-40 (PA) demonstrated prophylactic potency in swine infected experimentally with Haemophilus (Actinobacillus) pleuropneumoniae or Erysipelothrix rhusiopathiae. Animals received PA either together with the respective vaccine or PA only; 3 resp. 4 weeks later all animals were inoculated with virulent pathogens. Eight of 10 swine immunized with inactivated pleuropneumonia vaccine developed mild-moderate forms of infection with temporary stagnation of body weight; application of the vaccine together with PA lowered the morbidity rate to 1 of 10 (p < 0.05). Also in non-vaccinated swine infected with pleuropneumonia or erysipelas PA application resulted in milder clinical symptoms, faster recovery and a larger gain of body weight.
强效免疫调节剂嗜丙酸丙酸杆菌KP-40（PA）在实验感染胸膜肺炎放线杆菌（嗜血杆菌属）或猪丹毒杆菌的猪中显示出预防效力。动物要么同时接种PA和相应疫苗，要么只接种PA；分别在3周和4周后，所有动物都接种了强毒病原体。10只用灭活胸膜肺炎疫苗免疫的猪中有8只出现了轻度至中度感染形式，体重暂时停滞；将疫苗与PA一起使用可将发病率降至10只中的1只（p < 0.05）。同样，在感染胸膜肺炎或丹毒的未接种疫苗的猪中，应用PA也导致临床症状较轻、恢复较快且体重增加较多。
