Markowska-Daniel I, Pejsak Z, Szmigielski S, Jeljaszewicz J, Pulverer G
Department of Swine Diseases, National Institute of Veterinary Research, Pulawy, Poland.
Dtsch Tierarztl Wochenschr. 1993 Apr;100(4):149-51.
The usefulness of the prophylactic application of Propionibacterium avidum KP-40 (PA), a potent stimulator of the macrophage-monocyte system and inducer of endogenous interferons, was demonstrated in swine infected experimentally with Aujeszky's disease or classical swine fever viruses. Some of the infected animals were preimmunized with respective vaccines containing live, attenuated viruses. In vaccinated and non-vaccinated swine infected with Aujeszky's disease virus, pretreatment with PA lowered the morbidity rate, shortened the period of fever and fastened the recovery. Infection with classical swine fever virus resulted in 100% mortality of PA-pretreated non-vaccinated swine, but the length survival of the animals was significantly longer (p < 0.05).
在实验感染奥耶斯基氏病病毒或经典猪瘟病毒的猪身上，证明了痤疮丙酸杆菌KP-40（PA）（一种巨噬细胞-单核细胞系统的强效刺激剂和内源性干扰素诱导剂）预防性应用的有效性。一些感染动物用含有活的减毒病毒的相应疫苗进行了预免疫。在用奥耶斯基氏病病毒感染的接种和未接种疫苗的猪中，PA预处理降低了发病率，缩短了发热期并加速了康复。经典猪瘟病毒感染导致PA预处理的未接种疫苗的猪100%死亡，但动物的存活时间明显更长（p<0.05）。
