Pattinson R C, Odendaal H J, Kirsten G
Department of Obstetrics and Gynaecology and Paediatrics, Tygerberg Hospital, Parrowvallei, South Africa.
Early Hum Dev. 1993 Apr;33(1):61-9. doi: 10.1016/0378-3782(93)90173-r.
To determine the perinatal mortality and neonatal morbidity of fetuses with absent end-diastolic velocities (AEDV) of the umbilical artery, the outcome of 120 fetuses, with a gestational age of 24 weeks or more and a birth weight of 500 g or more, with AEDV at the last Doppler examination, were analyzed. The study population came from 348 women who had pregnancies at high risk of placental insufficiency and had had Doppler velocimetry examinations. In all the women, the Doppler velocimetry result was withheld from the clinician managing the woman. Of the fetuses with AEDV, 57 (52%) died and only 26 (22%) babies had minimal or no neonatal morbidity. All 24 fetuses with AEDVs delivering before 28 weeks gestation and having a birth weight less than 750 g died. When compared with fetuses from the study population with end-diastolic velocities present, the gestational age and birth weight at delivery was significantly lower, and the perinatal mortality, neonatal morbidity and number of light for gestational age (LGA) babies was significantly higher in the AEDV group. The LGA babies from both groups were compared by gestational age category and the LGA babies with AEDV still had a significantly higher perinatal mortality. There was no difference in the pattern of neonatal complications or causes of neonatal deaths between the two groups.
为了确定脐动脉舒张末期血流速度消失（AEDV）胎儿的围产期死亡率和新生儿发病率，对120例孕龄24周及以上、出生体重500克及以上且在最后一次多普勒检查时出现AEDV的胎儿结局进行了分析。研究人群来自348例有胎盘功能不全高危妊娠且接受过多普勒测速检查的女性。在所有这些女性中，向负责管理该女性的临床医生隐瞒了多普勒测速结果。在出现AEDV的胎儿中，57例（52%）死亡，只有26例（22%）婴儿有轻微或无新生儿发病率。所有24例孕龄小于28周、出生体重小于750克且出现AEDV的胎儿均死亡。与研究人群中舒张末期血流速度存在的胎儿相比，AEDV组的分娩孕周和出生体重显著更低，围产期死亡率、新生儿发病率以及小于胎龄儿（LGA）数量显著更高。按孕周类别对两组的LGA婴儿进行比较，出现AEDV的LGA婴儿围产期死亡率仍然显著更高。两组之间新生儿并发症模式或新生儿死亡原因没有差异。
