Wones R G, Deck C C, Stadler B, Roark S, Hogg E, Frohman L A
Department of Internal Medicine, University of Cincinnati College of Medicine, OH 45267.
Environ Health Perspect. 1993 Mar;99:369-74. doi: 10.1289/ehp.9399369.
The purpose of this study was to determine whether a 4-week consumption of 1.5L per day of drinking water containing monochloramine at a concentration of 2 ppm (ppm = mg/L) or 15 ppm under controlled conditions would alter parameters of lipid or thyroid metabolism in healthy men. Forty-eight men completed an 8-week protocol during which diet (600 mg cholesterol per day, 40% calories as fat) and other factors known to affect lipid metabolism were controlled. During the first 4 weeks of the protocol, all subjects consumed distilled water. During the second 4 weeks, one-third of the subjects were assigned randomly to drink 1.5 L per day of water containing 2 ppm of monochloramine, to drink 1.5 L per day of water containing 15 ppm monochloramine, or to continue drinking distilled water. Four blood samples were collected from each subject at the end of each 4-week study period. Subjects drinking monochloramine at a concentration of 2 ppm showed no significant changes in total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, apolipoproteins A1, A2, or B when compared to the distilled water group. Parameters of thyroid function also were unchanged by exposure to monochloramine at this concentration. However, subjects drinking monochloramine at a concentration of 15 ppm experienced an increase in the level of apolipoprotein B. Other parameters of lipid and thyroid metabolism did not change. We conclude that consumption of drinking water containing 2 ppm of monochloramine does not alter parameters of lipid and thyroid metabolism in healthy men. Consumption of water containing 15 ppm monochloramine may be associated with increased levels of plasma apolipoprotein B.
本研究的目的是确定在受控条件下，健康男性每天饮用1.5升浓度为2 ppm（ppm =毫克/升）或15 ppm的含一氯胺饮用水4周是否会改变脂质或甲状腺代谢参数。48名男性完成了一项为期8周的方案，在此期间，饮食（每天600毫克胆固醇，40%的热量来自脂肪）和其他已知影响脂质代谢的因素得到控制。在方案的前4周，所有受试者饮用蒸馏水。在第二个4周期间，三分之一的受试者被随机分配为每天饮用1.5升含2 ppm一氯胺的水、每天饮用1.5升含15 ppm一氯胺的水或继续饮用蒸馏水。在每个4周研究期结束时，从每个受试者采集4份血样。与蒸馏水组相比，饮用浓度为2 ppm一氯胺的受试者在总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、载脂蛋白A1、A2或B方面没有显著变化。接触该浓度的一氯胺也未改变甲状腺功能参数。然而，饮用浓度为15 ppm一氯胺的受试者载脂蛋白B水平有所升高。脂质和甲状腺代谢的其他参数没有变化。我们得出结论，饮用含2 ppm一氯胺的饮用水不会改变健康男性的脂质和甲状腺代谢参数。饮用含15 ppm一氯胺的水可能与血浆载脂蛋白B水平升高有关。
