Wones R G, Glueck C J
Environ Health Perspect. 1986 Nov;69:255-8. doi: 10.1289/ehp.8669255.
Atherosclerosis with its complications is the most important health problem affecting American adults. The levels of serum cholesterol, of high and low density lipoproteins, and of apolipoproteins A1, A2, and B are major risk factors for the development of atherosclerotic lesions. Animal studies suggest that chlorinated drinking water may elevate the serum cholesterol. Studies are too limited to confirm or refute this effect in humans. Since millions of humans have and have had daily exposure to chlorinated drinking water, it is essential to study the effects of such exposure on human lipid metabolism. We have begun a protocol to discover whether consuming chlorinated drinking water elevates serum cholesterol and the other lipid components of blood known to be associated with atherosclerosis. This protocol has been designed to improve the chance of observing an effect while preserving the ability to generalize the data.
动脉粥样硬化及其并发症是影响美国成年人的最重要的健康问题。血清胆固醇、高密度脂蛋白和低密度脂蛋白以及载脂蛋白A1、A2和B的水平是动脉粥样硬化病变发展的主要危险因素。动物研究表明，氯化饮用水可能会升高血清胆固醇。相关研究过于有限，无法证实或反驳其对人类的这种影响。由于数以百万计的人一直并且每天都在接触氯化饮用水，因此研究这种接触对人体脂质代谢的影响至关重要。我们已经启动了一项方案，以探究饮用氯化饮用水是否会升高血清胆固醇以及血液中其他已知与动脉粥样硬化相关的脂质成分。该方案旨在提高观察到某种影响的可能性，同时保留将数据进行推广的能力。
