Werder E A, Torresani T, Navratil F, Arbenz U, Eiholzer U, Pelet B, Burri M, Schwarzenbach P, Hunziker U
Kinderspital, Zürich, Switzerland.
Eur J Pediatr. 1993 May;152(5):397-8. doi: 10.1007/BF01955895.
In three children with Down syndrome and acquired hypothyroidism echocardiography was performed before and after the start of L-thyroxine treatment. Initial studies revealed pericardial effusions which resolved during treatment suggesting that they were caused by hypothyroidism. The incidence of hypothyroidism in Down syndrome is high, but the diagnosis is often missed for lack of specific clinical criteria. The finding of pericardial effusion by echocardiography may be essential in discovering thyroid dysfunction. The cases illustrate that regular thyroid function tests are important in Down syndrome.
在三名患有唐氏综合征并获得性甲状腺功能减退症的儿童中，在开始左甲状腺素治疗前后均进行了超声心动图检查。初始研究显示有心包积液，在治疗期间积液消失，提示积液是由甲状腺功能减退症引起的。唐氏综合征患者甲状腺功能减退症的发病率很高，但由于缺乏特定的临床标准，诊断常常被漏诊。超声心动图发现心包积液对于发现甲状腺功能障碍可能至关重要。这些病例表明，唐氏综合征患者定期进行甲状腺功能检查很重要。
