Dinleyici Ener Cagri, Ucar Birsen, Kilic Zubeyir, Dogruel Nesrin, Yarar Coskun
Department of Pediatrics, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.
Neuro Endocrinol Lett. 2007 Apr;28(2):141-4.
Pericardial effusion may be the first sign of congenital or acquired hypothyroidism and will completely resolve after thyroxin therapy. Hypothyroidism is more common in Down syndrome population than normal population. In this report we present four infants with Down syndrome who have pericardial effusion due to congenital hypothyroidism. All of these children with Down syndrome were admitted to our clinic with pericardial effusion. Pericardial effusion was completely resolved with thyroxin therapy without pericardiosentesis. Any child with Down syndrome who present with dyspnea and cardiomegaly should be suspected of having pericardial effusion due to hypothyroidism and echocardiography examination should be performed immediately. Pericardial effusion due to hypothyroidism will completely resolve with L-thyroxin therapy without pericardiosentesis. In conclusion, since a delayed diagnosis of hypothyroidism is likely and may favor the development of massive pericardial effusion and because of the difficult diagnosis of the hypothyroidism in Down syndrome, periodic follow-up of thyroid function tests are important.
心包积液可能是先天性或后天性甲状腺功能减退的首发症状，且在甲状腺素治疗后会完全消退。甲状腺功能减退在唐氏综合征人群中比正常人群更为常见。在本报告中，我们介绍了4例因先天性甲状腺功能减退而出现心包积液的唐氏综合征婴儿。所有这些患有唐氏综合征的儿童均因心包积液入住我们的诊所。心包积液通过甲状腺素治疗完全消退，无需进行心包穿刺术。任何出现呼吸困难和心脏扩大的唐氏综合征患儿都应怀疑因甲状腺功能减退而有心包积液，应立即进行超声心动图检查。因甲状腺功能减退导致的心包积液通过左甲状腺素治疗可完全消退，无需进行心包穿刺术。总之，由于甲状腺功能减退可能诊断延迟，且可能促使大量心包积液的形成，又因唐氏综合征中甲状腺功能减退的诊断困难，定期随访甲状腺功能检查很重要。
