Okazaki S, Sako K, Yonemasu Y
Department of Neurosurgery, Asahikawa Medical College, Japan.
Hokkaido Igaku Zasshi. 1993 May;68(3):311-7.
Neuropeptide Y (NPY) was continuously administered to Wistar rats in the normal and glioma bearing conditions intracarotidly via the external carotid artery and local cerebral blood flow (LCBF) was measured by a [14C] iodoantipyrine technique. In the normal rats, the LCBF at the injecting side of NPY markedly reduced in 2 minutes after beginning of drug administration. In glioma-bearing rats, LCBF in the cerebral cortex and caudate nucleus reduced to the same level as normal rats. However reduction of LCBF in the tumor was not significantly different from that of ipsilateral cortex and caudate nucleus. The results of this study suggest that flow moduration by NPY injection increases delivery of intra-carotid administered anticancer drugs to the brain tumor with concomitant decrease of neurotoxicity to the normal brain.
通过颈外动脉向正常和荷胶质瘤的Wistar大鼠颈动脉内持续注射神经肽Y（NPY），并采用[14C]碘安替比林技术测量局部脑血流量（LCBF）。在正常大鼠中，给药开始后2分钟，NPY注射侧的LCBF显著降低。在荷胶质瘤大鼠中，大脑皮层和尾状核的LCBF降低到与正常大鼠相同的水平。然而，肿瘤内LCBF的降低与同侧皮层和尾状核的降低没有显著差异。本研究结果表明，注射NPY调节血流量可增加经颈动脉给药的抗癌药物向脑肿瘤的递送，同时降低对正常脑的神经毒性。
