体外光化学疗法治疗进行性系统性硬化症
Extracorporeal photochemotherapy in progressive systemic sclerosis.
作者信息
Di Spaltro F X, Cottrill C, Cahill C, Degnan E, Mulford G J, Scarborough D, Franks A J, Klainer A S, Bisaccia E
机构信息
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York.
出版信息
Int J Dermatol. 1993 Jun;32(6):417-21. doi: 10.1111/j.1365-4362.1993.tb02811.x.
BACKGROUND
Extracorporeal photochemotherapy, an immune-modulating form of therapy, has been shown to be effective in the treatment of autoimmune diseases. We evaluated the effects of extracorporeal photochemotherapy in the treatment of patients with progressive systemic sclerosis (PSS).
METHODS
Nine patients with active progressive systemic sclerosis were treated with extracorporeal photochemotherapy on 2 successive days monthly. The duration of therapy ranged from 6 to 21 months.
RESULTS
A significant improvement was noted in the skin, musculoskeletal system, functional index, and symptoms including Raynaud's phenomenon, dyspnea, fatigue, dysphagia, and arthralgias, as well as improvement of cutaneous ulcers. Stabilization of the pulmonary function studies was also noted in the majority of patients over the course of therapy. No serious side effects were noted throughout the course of therapy in the 9 patients.
CONCLUSIONS
The results suggest that photopheresis may be beneficial in selected early cases of progressive systemic sclerosis.
背景
体外光化学疗法是一种免疫调节治疗方式，已被证明在自身免疫性疾病的治疗中有效。我们评估了体外光化学疗法对进行性系统性硬化症（PSS）患者的治疗效果。
方法
9例活动性进行性系统性硬化症患者每月连续2天接受体外光化学疗法治疗。治疗持续时间为6至21个月。
结果
皮肤、肌肉骨骼系统、功能指数以及包括雷诺现象、呼吸困难、疲劳、吞咽困难和关节痛在内的症状有显著改善，皮肤溃疡也有所改善。在治疗过程中，大多数患者的肺功能研究结果也趋于稳定。9例患者在整个治疗过程中均未出现严重副作用。
结论
结果表明，光分离置换法可能对部分早期进行性系统性硬化症病例有益。
Zotero 插件