Prieto V G, Casal M, McNutt N S
Department of Pathology, New York Hospital, Cornell University, Medical Center, New York.
J Cutan Pathol. 1993 Apr;20(2):143-7. doi: 10.1111/j.1600-0560.1993.tb00231.x.
Lichen planus-like keratosis (LPLK) (benign lichenoid keratosis) is a common skin lesion that shows some morphologic features of lichen planus (LP) and lichenoid actinic keratosis (LAK). To try to detect differences among these three entities, immunohistochemical staining for S100 protein and HLA-DR (with the antibody LN3) was performed in 31 cases of LPLK, 26 of LAK, and 25 of LP. Langerhans cells (LC) were counted per linear mm of epidermis in the S100 and LN3 slides. With anti-S100 staining, LP cases showed higher numbers of LC (mean = 25.3, SE = 2.84, median = 21.2) than did LPLK (mean = 17.3, SE = 2.26, median = 14.5) and LAK (mean = 9.7, SE = 1.5, median = 5.4). With LN3 stains, LP cases also showed higher numbers of LC than did LPLK and LAK. These results suggest that the involvement of LC in the production of lesions may be different in these three entities. However, due to the overlap in distribution of values observed, the use of these stains does not allow a definite diagnosis to be made exclusively based on the number of LC.
扁平苔藓样角化病（LPLK）（良性苔藓样角化病）是一种常见的皮肤损害，具有一些扁平苔藓（LP）和苔藓样日光性角化病（LAK）的形态学特征。为了试图检测这三种病变之间的差异，对31例LPLK、26例LAK和25例LP进行了S100蛋白和HLA - DR（使用抗体LN3）的免疫组织化学染色。在S100和LN3玻片上，每毫米表皮线性计数朗格汉斯细胞（LC）。抗S100染色显示，LP病例的LC数量（平均值 = 25.3，标准误 = 2.84，中位数 = 21.2）高于LPLK（平均值 = 17.3，标准误 = 2.26，中位数 = 14.5）和LAK（平均值 = 9.7，标准误 = 1.5，中位数 = 5.4）。LN3染色显示，LP病例的LC数量也高于LPLK和LAK。这些结果表明，LC参与病变形成在这三种病变中可能有所不同。然而，由于观察到的值分布存在重叠，使用这些染色不能仅根据LC数量做出明确诊断。
