Meira Z M, Mota C de C, Tonelli E, Nunan E A, Mitre A M, Moreira N S
Department of Pediatrics, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
J Pediatr. 1993 Jul;123(1):156-8. doi: 10.1016/s0022-3476(05)81563-x.
Serum concentrations of penicillin were measured in children with rheumatic fever. The adequacy of the values after administration of 1.2 million units of benzathine penicillin G every 2 or 3 weeks was confirmed; the adequacy of a 4-week regimen was questionable. The administration of 0.6 million units every 3 weeks was found to be inadequate to maintain serum levels high enough for the secondary prophylaxis of rheumatic fever.