Katsuya T, Ogihara T
Department of Geriatic Medicine, Osaka University Medical School.
Nihon Rinsho. 1993 Jun;51(6):1602-9.
SHR (spontaneously hypertensive rat) is the most popular genetic hypertensive model rat. Using the F2 progeny obtained from SHR and normotensive rats, for example, WKY (Wistar-Kyoto rat), many cosegregation studies to find the genes responsible for blood pressure have been done. In this review, we present some studies using F2 rats concerning candidate genes, renin, kallikrein, sodium potassium-ATPase, heat shock protein 70, angiotensin converting enzyme, phospholipase C-delta 1 and SA gene to show whether these genes really associate with blood pressure. We discuss the signification of these genes in the process of producing SHR and stroke-prone SHR from WKY. We hope these studies will lead to identify the mechanism of human essential hypertension.
自发性高血压大鼠（SHR）是最常用的遗传性高血压模型大鼠。例如，利用从SHR和正常血压大鼠（如WKY，即Wistar-Kyoto大鼠）获得的F2代后代，已经开展了许多共分离研究以寻找与血压相关的基因。在本综述中，我们介绍了一些使用F2大鼠针对候选基因（肾素、激肽释放酶、钠钾ATP酶、热休克蛋白70、血管紧张素转换酶、磷脂酶C-δ1和SA基因）开展的研究，以表明这些基因是否真的与血压相关。我们讨论了这些基因在从WKY产生SHR和易中风SHR过程中的意义。我们希望这些研究将有助于确定人类原发性高血压的机制。
