4号染色体上的神经肽Y基因座与自发性高血压大鼠的血压共分离。

A neuropeptide Y locus on chromosome 4 cosegregates with blood pressure in the spontaneously hypertensive rat.

作者信息

Katsuya T, Higaki J, Zhao Y, Miki T, Mikami H, Serikawa T, Ogihara T

机构信息

Department of Geriatric Medicine, Osaka University Medical School, Japan.

出版信息

Biochem Biophys Res Commun. 1993 Apr 15;192(1):261-7. doi: 10.1006/bbrc.1993.1408.

DOI:10.1006/bbrc.1993.1408

PMID:8476428

Abstract

Recent advances in molecular biology have allowed the study of the candidate genes for essential hypertension. To identify the genes responsible for basal blood pressure in the spontaneously hypertensive rat strain, the rat model of genetic hypertension, we performed a cosegregation analysis between the genotype and blood pressure in a set of male F2 progeny obtained from SHR and Wistar-Kyoto rats, a reference normotensive strain. Our investigation revealed that a locus on the chromosome 4 cosegregates with the blood pressure in SHR, especially at neuropeptide Y locus. The degree of cosegregation with all values of blood pressure without sodium loading was moderate but consistent. We propose that neuropeptide Y locus on chromosome 4 is a new candidate for the hypertensive effect in original SHR.

摘要

分子生物学的最新进展使得对原发性高血压候选基因的研究成为可能。为了鉴定遗传性高血压大鼠模型——自发性高血压大鼠品系中负责基础血压的基因，我们在一组从自发性高血压大鼠（SHR）和作为正常血压对照品系的Wistar-Kyoto大鼠获得的雄性F2后代中，对基因型和血压进行了共分离分析。我们的研究表明，4号染色体上的一个位点与自发性高血压大鼠的血压共分离，尤其是在神经肽Y位点。在无钠负荷情况下，该位点与所有血压值的共分离程度中等但具有一致性。我们提出，4号染色体上的神经肽Y位点是原始自发性高血压大鼠中高血压效应的一个新候选基因。