McKerrow J H, Ritter D M
Department of Pathology, University of California, San Francisco.
Lab Anim Sci. 1993 Apr;43(2):136-8.
The interaction between parasites and their animal or human hosts is one of the most interesting and important biologic phenomena. Understanding the host-parasite interplay is essential to understanding the pathogenesis of parasitic diseases and for the development of new vaccines and chemotherapy. One approach to identifying key components of the host immune response to parasites is using immunodeficient host models. Scid mice are one of the most useful models of an immunodeficient host. Herein, we describe the use of scid mice to identify the steps in granuloma formation to parasite eggs, devise a screening model for vaccine development, and provide clues to the pathogenesis of opportunistic infections associated with AIDS.
寄生虫与其动物或人类宿主之间的相互作用是最有趣且最重要的生物学现象之一。了解宿主与寄生虫之间的相互作用对于理解寄生虫病的发病机制以及开发新疫苗和化疗方法至关重要。识别宿主对寄生虫免疫反应关键成分的一种方法是使用免疫缺陷宿主模型。重度联合免疫缺陷（Scid）小鼠是免疫缺陷宿主最有用的模型之一。在此，我们描述了使用Scid小鼠来确定肉芽肿形成至寄生虫卵的步骤，设计用于疫苗开发的筛选模型，并为与艾滋病相关的机会性感染的发病机制提供线索。
