Johnson P D, Dawson B V, Goldberg S J
Department of Pediatric Cardiology, University of Arizona, Tucson 85724.
Lab Anim Sci. 1993 Apr;43(2):183-8.
The incidence rate of spontaneous congenital cardiac defects in Sprague Dawley rats has not been extensively studied. The incidence of general congenital defects in these animals has been thoroughly investigated and is very low. We sought to determine the prevalence of congenital heart defects in Sprague Dawley rats. Teratology studies using mammalian models have become increasingly important as the number of known environmental contaminants has increased; thus, it is essential to know the incidence of spontaneous congenital cardiac defects in this most commonly used mammalian model so that statistically appropriate research protocols can be planned. Using a thorough method of evaluating the structure of the heart, 624 Sprague Dawley fetal rat hearts were examined just before parturition. Animals used in this study were control groups for surgically manipulated, hydrocarbon-treated animals in a study by Dawson et al. in 1990. The overall incidence of spontaneous congenital cardiac defects was found to be 2.3%. This is similar to the incidence of congenital cardiac defects in humans and thus enhances the suitability of Sprague Dawley rats as a small mammalian model to study the factors that affect cardiac development.
尚未对斯普拉格-道利大鼠自发性先天性心脏缺陷的发病率进行广泛研究。这些动物中一般先天性缺陷的发病率已得到充分调查，且非常低。我们试图确定斯普拉格-道利大鼠先天性心脏缺陷的患病率。随着已知环境污染物数量的增加，使用哺乳动物模型的致畸学研究变得越来越重要；因此，了解这种最常用的哺乳动物模型中自发性先天性心脏缺陷的发病率至关重要，以便能够制定出统计学上合适的研究方案。采用全面评估心脏结构的方法，在分娩前对624只斯普拉格-道利胎鼠心脏进行了检查。本研究中使用的动物是1990年道森等人研究中经手术操作、碳氢化合物处理动物的对照组。发现自发性先天性心脏缺陷的总体发病率为2.3%。这与人类先天性心脏缺陷的发病率相似，因此提高了斯普拉格-道利大鼠作为小型哺乳动物模型来研究影响心脏发育因素的适用性。
