具有时间延迟的多室模型中的平均驻留时间。
Mean residence time in multicompartmental models with time delays.
作者信息
Plusquellec Y, Houin G
机构信息
UFR de Mathématiques, Université Paul Sabatier, Toulouse, France.
出版信息
J Biomed Eng. 1993 May;15(3):240-6. doi: 10.1016/0141-5425(93)90121-e.
PMID:8320984
Abstract
Calculation of the mean residence time (MRT) of a drug in a stationary compartmental model is classically carried out from several expressions. Nevertheless, one or more time delays between compartments modify the mean residence times. It is the aim of this paper to propose a general method for MRT calculations, in any n-compartmental models which may include time delays. As examples, catenary and mammillary models are considered.
摘要
在固定房室模型中，药物平均驻留时间（MRT）的计算通常通过几种表达式来进行。然而，房室之间的一个或多个时间延迟会改变平均驻留时间。本文的目的是提出一种在任何可能包含时间延迟的n房室模型中进行MRT计算的通用方法。作为示例，考虑了链式模型和乳头状模型。
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