Kanbara Y, Kono N, Nakaya M, Ishikawa Y, Fujiwara O, Kitazawa R, Kitazawa S
Department of Surgery, Hyogo Medical Center for Adult, Akashi, Japan.
Nihon Geka Gakkai Zasshi. 1993 Apr;94(4):394-9.
PTHrP is the main factor of humoral hypercalcemia of malignancy. PTHrP produces the same effect on renal and osteoblast membrane in vitro and on calcium and inorganic phosphate fluxes in vivo as human PTH. Physiologically, PTHrP is produced by rat mammary tissue during lactation. It is suggested that PTHrP correlates to the metabolism of calcium in the mammary gland. Using anti-PHTrP (1-34) monoclonal antibody 4B3, we investigated the correlation of PTHrP and calcification in breast cancer. All the breast cancers with calcification on mammography showed positive immunostaining. Most cases without calcification, on the other hand, showed negative. Positive PTHrP staining was not related to the any clinical parameter. It is suspected that PTHrP is also one of the main factors of calcification in breast cancer.
甲状旁腺激素相关蛋白（PTHrP）是恶性肿瘤体液性高钙血症的主要因素。PTHrP在体外对肾和成骨细胞膜以及在体内对钙和无机磷通量产生与人甲状旁腺激素（PTH）相同的作用。生理情况下，大鼠乳腺组织在哺乳期产生PTHrP。提示PTHrP与乳腺中钙的代谢相关。使用抗PTHrP（1 - 34）单克隆抗体4B3，我们研究了PTHrP与乳腺癌钙化的相关性。所有乳腺钼靶检查有钙化的乳腺癌均显示免疫染色阳性。另一方面，大多数无钙化的病例显示为阴性。PTHrP染色阳性与任何临床参数均无关。怀疑PTHrP也是乳腺癌钙化的主要因素之一。
