Recordare A, Bellusci R, Gaiani S, Cavallari A, Gozzetti G
Istituto di Clinica Chirurgica II, Università degli Studi di Bologna, Policlinico S. Orsola.
Minerva Chir. 1993 Apr 30;48(8):425-30.
We report on a case of early portal vein thrombosis occurring after liver transplantation in a patient with alcoholic cirrhosis. Although this complication is usually accompanied by acute graft failure and/or gastroesophageal bleeding, in this patient the portal thrombosis occurred with the appearance of general dropsy and encephalopathy, serum protein deficiency and a slight rise in liver function test values. Echo-Doppler and arteriography showed portal thrombosis, arterial hyperflow and the persistence of a large spontaneous spleno-renal shunt, identified before the transplant had taken place. Endoscopy did not reveal gastroesophageal varices. Since there was no sign of serious ischemic damage or of a serious deterioration of liver function, the patient was treated non-operatively. Some particular hemodynamic aspects implicated in the appearance of portal thrombosis in our case are discussed. However, the authors consider that spontaneous portal-systemic shunt, in the presence of advanced cirrhosis, inverted portal flow, without gastroesophageal varices, can be considered as a surgical total diverting shunt and should be taken as a risk for portal thrombosis after transplantation.
我们报告了一例酒精性肝硬化患者肝移植后早期发生门静脉血栓形成的病例。尽管这种并发症通常伴有急性移植物功能衰竭和/或胃食管出血,但该患者门静脉血栓形成时伴有全身性水肿和脑病、血清蛋白缺乏以及肝功能检查值略有升高。超声多普勒和动脉造影显示门静脉血栓形成、动脉血流增加以及移植前就已发现的较大自发性脾肾分流持续存在。内镜检查未发现胃食管静脉曲张。由于没有严重缺血损伤或肝功能严重恶化的迹象,对该患者进行了非手术治疗。讨论了我们病例中门静脉血栓形成所涉及的一些特殊血流动力学方面。然而,作者认为,在晚期肝硬化、门静脉血流反向且无胃食管静脉曲张的情况下,自发性门体分流可被视为手术性完全分流,应被视为移植后门静脉血栓形成的一个风险因素。