Hu M W, Matheson L E
Lederle Laboratories, Pearl River, New York 10965.
Pharm Res. 1993 May;10(5):732-6. doi: 10.1023/a:1018968001793.
The steady-state flux of 35 substituted pyridine derivatives was determined in polydimethylsiloxane membranes using isopropyl alcohol as the receiver solvent. These diffusants constituted a diverse group of compounds possessing a wide range of hydrophobic, steric, and electronic characteristics. Various parameters representing these physicochemical properties such as cyclohexane-water fragmental constants, molar refractivity, Hammett's sigma constants, melting point, and mole fraction solubility were employed to develop empirical models capable of relating the flux to these characteristics of either the substituent on the pyridine ring or the compound itself.
使用异丙醇作为接收溶剂，在聚二甲基硅氧烷膜中测定了35种取代吡啶衍生物的稳态通量。这些扩散剂构成了一组具有广泛疏水、空间和电子特性的化合物。采用各种代表这些物理化学性质的参数，如环己烷-水片段常数、摩尔折射率、哈米特σ常数、熔点和摩尔分数溶解度，来建立能够将通量与吡啶环上取代基或化合物本身的这些特性相关联的经验模型。
