Fontaine M, Valli V E, Young L G, Lumsden J H
Can J Comp Med. 1977 Jan;41(1):41-51.
Pigs which were deficient in vitamin E and/or selenium had the following parameters weekly determined from six to 13 weeks of age: Packed cell volume, hemoglobin concentration, red cell and white cell counts, red cell indices, reticulocyte count, serum iron, serum total iron binding capacity, myeloid: erythroid ratio, serum glutamic-oxaloacetic transaminase and creatine phosphokinase activities and body weight. Except for the myeloid:erythroid ratio and serum creatine phosphokinase activity, these parameters were not found to be significantly affected by either vitamin E deficiency, selenium deficiency or deficiency of both. The myeloid:erythroid ratio was increased (p less than 0.01) in association with selenium deficiency, which tends to indicate decreased erythropoiesis but was not reflected in the peripheral red cell picture. Evidence of dyserythropoiesis was not found to be a significant feature in serial bone marrow aspiration biopsies of vitamin E and/or selenium deficient pigs. Even if the serum glutamic-oxaloacetic transaminase activities were not found to be significantly affected by either vitamin E deficiency, selenium deficiency or deficiency in both as compared to replete animals, a few animals, especially in the group deficient in both vitamin E and selenium, presented quite marked transient increases of serum glutamic-oxaloacetic transaminase activity which was interpreted to reflect the occurrence of acute episodes of hepatosis dietetica. Serum creatine phosphokinase activities were found to be increased in association with vitamin E deficiency (p less than 0.01), selenium deficiency (less than 0.05) and the interaction was also significant (p less than 0.01). It was concluded that the serum creatine phosphokinase activity increases reflect the occurrence of subclinical muscular dystrophy and that vitamin E and selenium deficiencies have marked additive effects in the induction of skeletal muscular dystrophy.
对维生素E和/或硒缺乏的猪，在6至13周龄期间每周测定以下参数：红细胞压积、血红蛋白浓度、红细胞和白细胞计数、红细胞指数、网织红细胞计数、血清铁、血清总铁结合力、髓系：红系比例、血清谷草转氨酶和肌酸磷酸激酶活性以及体重。除髓系：红系比例和血清肌酸磷酸激酶活性外，未发现这些参数受维生素E缺乏、硒缺乏或两者缺乏的显著影响。与硒缺乏相关的髓系：红系比例升高（p<0.01），这倾向于表明红细胞生成减少，但在外周红细胞情况中未得到体现。在维生素E和/或硒缺乏猪的系列骨髓穿刺活检中，未发现红细胞生成异常是一个显著特征。即使与营养充足的动物相比，未发现血清谷草转氨酶活性受维生素E缺乏、硒缺乏或两者缺乏的显著影响，但一些动物，尤其是维生素E和硒均缺乏的组中，出现了血清谷草转氨酶活性相当明显的短暂升高，这被解释为反映了营养性肝病急性发作的发生。发现血清肌酸磷酸激酶活性与维生素E缺乏（p<0.01）、硒缺乏（<0.05）相关，且两者的相互作用也显著（p<0.01）。得出的结论是，血清肌酸磷酸激酶活性升高反映了亚临床肌肉营养不良的发生，并且维生素E和硒缺乏在诱导骨骼肌营养不良方面具有显著的相加作用。
