Angulo J C, Lopez J I, Flores N
Department of Urology, Santo Hospital Civil de Bilbao, Spain.
Minerva Urol Nefrol. 1993 Mar;45(1):19-22.
We present two cases of urologic malignancies, transitional cell carcinoma of the bladder and renal cell carcinoma respectively, closely associated to progressive systemic sclerosis. The relationship between such neoplasms and immune disorders is thereof reviewed. Cancer may develop in a context of diminished immunological surveillance. Conversely, autoimmunity can also be secondary to neoplasia and somehow understood as paraneoplastic. Anyway, the cases here reported could be regarded as unusual associations that may reproduce the still unclear connections between immunity and neoplasia.
我们报告了两例泌尿系统恶性肿瘤病例，分别为膀胱移行细胞癌和肾细胞癌，它们与进行性系统性硬化症密切相关。本文就此类肿瘤与免疫紊乱之间的关系进行了综述。癌症可能在免疫监视减弱的情况下发生。相反，自身免疫也可能继发于肿瘤形成，并在某种程度上被视为副肿瘤性的。无论如何，此处报告的病例可被视为不寻常的关联，它们可能重现了免疫与肿瘤形成之间仍不清楚的联系。
