Rosenberg A G, Dexeus F, Swanson D A, von Eschenbach A C
Department of Urology, University of Texas M.D. Anderson Cancer Center, Houston.
Urology. 1990 Jun;35(6):492-8. doi: 10.1016/0090-4295(90)80101-r.
Thyroid hormone participates in numerous cellular functions besides thermogenesis and metabolism. Several studies, including the recent identification of the product of an oncogene, c-erb-A, as a thyroid-hormone receptor, have shown possible involvement of thyroid hormone in the process of carcinogenesis. A recent anecdotal observation of an unusually high incidence of thyroid dysfunction in women with renal cell carcinoma led to a retrospective review of the incidence and distribution of thyroid disorders in women with renal cell carcinoma compared with a control group of women with transitional cell carcinoma of the renal pelvis, ureter, bladder, or urethra. Women with renal cell carcinoma had a statistically significantly higher percentage of hypothyroidism, thyroid disease in general, and the use of thyroid-hormone supplements as compared with the control group (P = 0.033, P = 0.005, P = 0.041, respectively). The nature of the relationship, however, could not be determined. These findings add a new dimension to renal cell carcinoma, and prospective studies are encouraged to define the contribution of thyroid hormone to renal cell carcinogenesis.
甲状腺激素除了参与产热和新陈代谢外，还参与许多细胞功能。包括最近将一种癌基因c-erb-A的产物鉴定为甲状腺激素受体在内的多项研究表明，甲状腺激素可能参与致癌过程。最近有一则轶事观察发现，肾细胞癌女性患者甲状腺功能障碍的发生率异常高，这促使人们对肾细胞癌女性患者与肾盂、输尿管、膀胱或尿道移行细胞癌女性对照组相比，甲状腺疾病的发生率和分布情况进行回顾性研究。与对照组相比，肾细胞癌女性患者甲状腺功能减退、总体甲状腺疾病以及使用甲状腺激素补充剂的比例在统计学上显著更高（分别为P = 0.033、P = 0.005、P = 0.041）。然而，这种关系的性质尚无法确定。这些发现为肾细胞癌增添了新的维度，鼓励开展前瞻性研究以明确甲状腺激素对肾细胞癌发生发展的作用。
