Ikeda J, Furuyama M, Sakuma T, Katoh A, Sugi M, Takita T, Maehara K, Takishima T, Shirato K
First Department of Internal Medicine, Tohoku University, School of Medicine, Miyagi, Japan.
Am Heart J. 1993 Jul;126(1):130-5. doi: 10.1016/s0002-8703(07)80019-6.
Elevation of plasma catecholamine levels during exercise in patients with mitral stenosis correlated with the severity of the disease. We investigated the plasma norepinephrine changes in six patients before and after percutaneous transluminal mitral valvuloplasty (PTMV) during continuously graded ergometer exercise. Peak exercise intensity was increased from 65.8 W to 87.5 W after PTMV. Plasma norepinephrine level at 60 W workload intensity was decreased from 2308 +/- 864 pg/ml to 841 +/- 233 pg/ml after PTMV (p < 0.05). We concluded that PTMV decreased the plasma norepinephrine level during exercise in the patients with mitral stenosis. Percutaneous transluminal mitral valvuloplasty is a novel procedure for the improvement of symptoms in patients with mitral stenosis.
二尖瓣狭窄患者运动期间血浆儿茶酚胺水平的升高与疾病严重程度相关。我们对6例患者在连续分级测力计运动期间经皮腔内二尖瓣成形术（PTMV）前后的血浆去甲肾上腺素变化进行了研究。PTMV后，运动峰值强度从65.8瓦增加到87.5瓦。在60瓦工作负荷强度下，PTMV后血浆去甲肾上腺素水平从2308±864皮克/毫升降至841±233皮克/毫升（p<0.05）。我们得出结论，PTMV降低了二尖瓣狭窄患者运动期间的血浆去甲肾上腺素水平。经皮腔内二尖瓣成形术是改善二尖瓣狭窄患者症状的一种新方法。
