Vadlamudi R K, McCormick R J, Medeiros D M, Vossoughi J, Failla M L
Department of Animal Science, University of Wyoming, Laramie 82071.
Am J Physiol. 1993 Jun;264(6 Pt 2):H2154-61. doi: 10.1152/ajpheart.1993.264.6.H2154.
Dietary copper deficiency induces alterations of connective tissue metabolism that are associated with lesions in cardiovascular and other organ systems. To determine the impact of copper deficiency on characteristics of collagen in porcine myocardium and cardiac valves, weaned pigs were fed diets with adequate or deficient levels of copper. Although dietary copper did not affect the concentration of collagen in either myocardium or bicuspid valves, the degree of collagen cross-linking, as assessed by the level of hydroxylysylpyridinoline, was lower in both tissues of copper-deficient pigs. Proportions of type III collagen were increased in the left ventricle and bicuspid valves of copper-deficient pigs. Copper deficiency induced extensive remodeling, however, of the collagen fraction of cardiac interstitium. Reduction in left ventricular collagen cross-linking may provide the stimulus for the development of cardiac hypertrophy, which characterizes severe copper deficiency, by increasing the compliance of the ventricular wall. The shift in the phenotypic profile of collagen that is associated with this cardiac hypertrophy indicates synthesis of new collagen, which could affect collagen cross-linking irrespective of copper status.
膳食铜缺乏会导致结缔组织代谢改变，这与心血管和其他器官系统的病变有关。为了确定铜缺乏对猪心肌和心脏瓣膜中胶原蛋白特性的影响，给断奶仔猪喂食铜含量充足或缺乏的日粮。尽管日粮铜对心肌或二尖瓣中胶原蛋白的浓度没有影响，但通过羟赖氨酸吡啶啉水平评估的胶原蛋白交联程度在铜缺乏仔猪的这两种组织中均较低。铜缺乏仔猪左心室和二尖瓣中III型胶原蛋白的比例增加。然而，铜缺乏引起了心脏间质胶原蛋白部分的广泛重塑。左心室胶原蛋白交联的减少可能通过增加心室壁的顺应性，为心脏肥大的发展提供刺激，而心脏肥大是严重铜缺乏的特征。与这种心脏肥大相关的胶原蛋白表型特征的转变表明合成了新的胶原蛋白，这可能会影响胶原蛋白的交联，而与铜状态无关。
