Redman R S, Fields M, Reiser S, Smith J C
Oral Pathology Research Laboratory, Veterans Administration Medical Center, Washington, DC 20422.
Atherosclerosis. 1988 Dec;74(3):203-14. doi: 10.1016/0021-9150(88)90239-0.
Copper deficiency has been shown to result in severe cardiovascular lesions in several species of animals. The principal carbohydrate in the copper-deficient diet most often used with rats is sucrose, which is known to have adverse effects on carbohydrate and lipid metabolism and thus may contribute to cardiovascular disorders. These observations prompted experiments in which starch and fructose were substituted for sucrose in a copper-deficient diet, to see if the effects of the copper deficiency might be modified. In the hearts from rats fed copper-deficient diets with fructose or sucrose, there was marked, mostly ventricular hypertrophy, and mild to severe myocardial inflammation, degeneration, and fibrosis. Aneurysm of the left ventricle and pericarditis also were common. Hearts from the starch, copper-deficient groups were much less hypertrophic, and very few were affected by myocardial inflammation, degeneration, or fibrosis. Defects of elastin or other structures were not observed in the aortas or pulmonary or coronary arteries of any specimens.
铜缺乏已被证明会在几种动物中导致严重的心血管病变。在常用于大鼠的缺铜饮食中，主要的碳水化合物是蔗糖，已知蔗糖对碳水化合物和脂质代谢有不良影响，因此可能导致心血管疾病。这些观察结果促使人们进行实验，用淀粉和果糖替代缺铜饮食中的蔗糖，以观察缺铜的影响是否可能得到改善。在喂食含果糖或蔗糖的缺铜饮食的大鼠心脏中，有明显的、主要是心室肥大，以及轻度至重度的心肌炎症、变性和纤维化。左心室动脉瘤和心包炎也很常见。来自淀粉缺铜组的心脏肥大程度要小得多，很少受到心肌炎症、变性或纤维化的影响。在任何标本的主动脉、肺动脉或冠状动脉中均未观察到弹性蛋白或其他结构的缺陷。
