Jackson C E, Barohn R J, Mendell J R
Department of Medicine, University of Texas Health Science Center, San Antonio 78284-7883.
Arch Neurol. 1993 Jul;50(7):732-5. doi: 10.1001/archneur.1993.00540070050014.
To define clinically an unusual acute paralytic syndrome with features distinctive from those of the Guillain-Barré syndrome and similar to those described in Chinese children and young adults.
Case series.
University medical centers.
Three North American men (mean age, 29 years) who presented with acute symmetric weakness and muscle cramps after a preceding gastrointestinal tract illness. These patients had no sensory symptoms, developed no respiratory insufficiency or facial weakness, and had normal to brisk muscle stretch reflexes.
Results of serial nerve conduction studies were normal except for low-amplitude motor potentials. Needle electromyography revealed diffuse denervation potentials. Cerebrospinal fluid showed an elevated protein level and, in one case, a mild pleocytosis. A sural nerve biopsy specimen in one patient was normal; muscle biopsy specimens showed denervation atrophy.
These cases resemble those described in Chinese children and young adults and may represent a postviral monophasic process affecting the anterior horn cell or distal motor nerve terminal. Further pathologic correlation will be required to identify the exact site of the lesion. Differentiation is important when considering modes of treatment.
临床上定义一种不寻常的急性麻痹综合征，其特征与吉兰 - 巴雷综合征不同，与中国儿童和年轻人中描述的综合征相似。
病例系列。
大学医学中心。
三名北美男性（平均年龄29岁），在先前的胃肠道疾病后出现急性对称性无力和肌肉痉挛。这些患者无感觉症状，未出现呼吸功能不全或面部无力，肌肉牵张反射正常至活跃。
除运动电位幅度低外，系列神经传导研究结果正常。针极肌电图显示弥漫性失神经电位。脑脊液显示蛋白水平升高，一例有轻度细胞增多。一名患者的腓肠神经活检标本正常；肌肉活检标本显示失神经萎缩。
这些病例与中国儿童和年轻人中描述的病例相似，可能代表一种影响前角细胞或远端运动神经末梢的病毒感染后单相过程。需要进一步的病理相关性研究以确定病变的确切部位。在考虑治疗方式时，鉴别诊断很重要。
