Hart J, Lewis P J, Lesser R P, Fisher R S, Monsein L H, Schwerdt P, Bandeen-Roche K, Gordon B
Arch Neurol. 1993 Jul;50(7):745-50. doi: 10.1001/archneur.1993.00540070059016.
To better identify regions of the brain affected by intracarotid amobarbital injections and to more precisely predict whether resections of specific brain regions will cause postoperative memory deficits.
We modified the standard intracarotid amobarbital procedure by adding a radioactive tracer to the amobarbital injection, thereby providing better correlation between behavior and deactivated brain region.
Tertiary-care hospital center with a dedicated program for medical and surgical treatment of epilepsy.
We studied 39 patients with medically intractable epilepsy drawn from a regional referral base.
Intracarotid injection of 125 mg of sodium amobarbital with 37 MBq of technetium Tc 99m hexamethylpropyleneamine oxime (HMPAO), followed by language and memory testing.
The distribution of amobarbital as measured by single photon emission computed tomographic imaging of HMPAO and patient performance on memory tasks.
Medial temporal regions were irrigated by the amobarbital in only 28% of the injections. Overall, findings suggest that medial temporal and lateral neotemporal cortex play a role in memory.
The regions involved in memory function vary by individual, as does the distribution of amobarbital. Thus, the most accurate method of determining correlation of brain region with memory function during intracarotid amobarbital injection involves the use of a tracer such as HMPAO.
更好地识别经颈动脉注射异戊巴比妥后受影响的脑区，并更精确地预测特定脑区的切除是否会导致术后记忆缺陷。
我们对标准的经颈动脉异戊巴比妥程序进行了改良，在异戊巴比妥注射液中添加了放射性示踪剂，从而在行为与失活脑区之间建立了更好的相关性。
一家三级护理医院中心，设有专门的癫痫内科和外科治疗项目。
我们研究了从区域转诊库中选取的39例药物难治性癫痫患者。
经颈动脉注射125毫克异戊巴比妥钠和37兆贝可的锝Tc 99m六甲基丙烯胺肟（HMPAO），随后进行语言和记忆测试。
通过HMPAO单光子发射计算机断层扫描成像测量的异戊巴比妥分布以及患者在记忆任务中的表现。
仅28%的注射中，异戊巴比妥灌注到了内侧颞叶区域。总体而言，研究结果表明内侧颞叶和外侧新颞叶皮质在记忆中起作用。
参与记忆功能的脑区因人而异，异戊巴比妥的分布也是如此。因此，在经颈动脉注射异戊巴比妥期间，确定脑区与记忆功能相关性的最准确方法是使用HMPAO等示踪剂。
