Eberling J L, Reed B R, Baker M G, Jagust W J
Center for Functional Imaging, Lawrence Berkeley Laboratory, University of California, Berkeley 94720.
Arch Neurol. 1993 Jul;50(7):761-6. doi: 10.1001/archneur.1993.00540070073019.
To study the relationship between relative regional cerebral blood flow (rCBF) and performance on a variety of neuropsychological tests in a group of subjects with Alzheimer's disease.
Analysis of the relationship between relative rCBF and neuropsychological performance using stepwise multiple regressions and Pearson Product-Moment Correlation coefficients.
University dementia clinic and research laboratory.
Twelve mildly demented patients with Alzheimer's disease (Mini-Mental State examination [MMSE] scores, 24 to 29; age, 56 to 78 years); 38 moderately demented patients with Alzheimer's disease (MMSE scores, 0 to 23; age, 59 to 86 years); and eight normal control subjects (MMSE scores, 27 to 30; age, 61 to 79 years).
Single photon emission computed tomography and the blood flow tracer N-isopropyl-p-iodoamphetamine iodine 123 were used to measure relative rCBF. Cognitive performance was assessed by grouping neuropsychological tests into clusters reflecting frontal lobe abilities, perseveration, memory, and visuoconstructive abilities.
While MMSE score was a significant (P < .05) predictor of visuoconstruction, frontal lobe, and memory cluster scores, relative rCBF was a weaker predictor of neuropsychological performance, with only right orbitofrontal relative rCBF emerging as a significant (P < .05) predictor of the frontal cluster score and right parietal relative rCBF as a significant (P < .05) predictor of the visuoconstruction cluster score.
These results support our a priori grouping of neuropsychological tests into frontal and visuoconstruction clusters and suggest that these two clusters are good measures of frontal and parietal lobe function, respectively.
研究一组阿尔茨海默病患者的相对局部脑血流量（rCBF）与多种神经心理学测试表现之间的关系。
使用逐步多元回归和皮尔逊积差相关系数分析相对rCBF与神经心理学表现之间的关系。
大学痴呆症诊所和研究实验室。
12名轻度痴呆的阿尔茨海默病患者（简易精神状态检查表[MMSE]评分，24至29分；年龄，56至78岁）；38名中度痴呆的阿尔茨海默病患者（MMSE评分，0至23分；年龄，59至86岁）；以及8名正常对照受试者（MMSE评分，27至30分；年龄，61至79岁）。
使用单光子发射计算机断层扫描和血流示踪剂N-异丙基-p-碘安非他明碘123测量相对rCBF。通过将神经心理学测试分组为反映额叶能力、持续性、记忆和视觉构建能力的集群来评估认知表现。
虽然MMSE评分是视觉构建、额叶和记忆集群评分的显著（P <.05）预测指标，但相对rCBF是神经心理学表现的较弱预测指标，只有右侧眶额叶相对rCBF作为额叶集群评分的显著（P <.05）预测指标出现，右侧顶叶相对rCBF作为视觉构建集群评分的显著（P <.05）预测指标出现。
这些结果支持我们将神经心理学测试预先分组为额叶和视觉构建集群，并表明这两个集群分别是额叶和顶叶功能的良好测量指标。
