Eberling J L, Jagust W J, Reed B R, Baker M G
Donner Laboratory, Lawrence Berkeley Laboratory, University of California, Berkeley 94720.
Neurobiol Aging. 1992 Jul-Aug;13(4):483-91. doi: 10.1016/0197-4580(92)90076-a.
We used single photon emission computed tomography with the blood flow tracer [123I]N-isopropyl-p-iodoamphetamine (IMP) to study regional cerebral blood flow (rCBF) in 50 mildly and moderately demented Alzheimer's disease (AD) patients to evaluate rCBF as a function of disease severity. Relative rCBF (normalized to occipital cortex) was significantly lower than controls in temporal cortex for both mildly and moderately demented patients. Similar numbers of patients in both groups demonstrated perfusion abnormalities in temporal neocortex. Parietal cortex was more variably involved with greater numbers of moderately than mildly demented patients showing perfusion abnormalities. Relative rCBF in dirsolateral frontal cortex was reduced only in the moderately demented patients. Disease severity, as measured by the Mini Mental Status Examination, was associated with relative rCBF only in dorsolateral frontal and parietal cortex. These results suggest that the temporal lobes are the first neocortical regions affected by AD and that other cortical areas become involved as the disease progresses.
我们使用单光子发射计算机断层扫描技术，借助血流示踪剂[123I]N-异丙基-p-碘安非他明（IMP），对50例轻度和中度痴呆的阿尔茨海默病（AD）患者的局部脑血流量（rCBF）进行了研究，以评估rCBF作为疾病严重程度的函数。轻度和中度痴呆患者颞叶的相对rCBF（相对于枕叶皮质进行标准化）均显著低于对照组。两组中出现颞叶新皮质灌注异常的患者数量相似。顶叶皮质受累情况变化较大，中度痴呆患者出现灌注异常的人数多于轻度痴呆患者。仅在中度痴呆患者中，双侧额叶皮质的相对rCBF降低。通过简易精神状态检查表测量的疾病严重程度，仅与双侧额叶皮质和顶叶皮质的相对rCBF相关。这些结果表明，颞叶是受AD影响的首个新皮质区域，并且随着疾病进展其他皮质区域也会受累。
