Becciolini A, Porciani S, Lanini A, Tommasi M, Olmi P, Chiavacci A
Department of Clinical Physiopathology, The University, Florence, Italy.
Acta Oncol. 1993;32(3):295-9. doi: 10.3109/02841869309093598.
The serum tissue polypeptide antigen (TPA) was determined before and at the end of radiotherapy in a group of patients with head and neck epidermoid carcinoma. The baseline values were significantly higher than those in healthy control subjects. They did not depend on the site of the neoplasia but increased with clinical stage. A cut-off value of 85 U/l discriminated two groups of patients according to survival: patients whose values were lower than the cut-off had a disease-free 6-year survival rate of 61%, compared to only 22% in patients with higher TPA levels. Until the second year of follow-up, patients with complete response had baseline values significantly lower than relapsed patients. However, at 5 years the pretreatment values were similar for patients being disease-free, patients with recurrence and patients deceased within the 2-5 year period.
在一组头颈部表皮样癌患者放疗前及放疗结束时测定血清组织多肽抗原（TPA）。基线值显著高于健康对照受试者。它们不取决于肿瘤的部位，但随临床分期增加。85 U/l的临界值根据生存率区分两组患者：TPA值低于临界值的患者6年无病生存率为61%，而TPA水平较高的患者仅为22%。直到随访第二年，完全缓解的患者基线值显著低于复发患者。然而，在5年时，无病患者、复发患者以及在2至5年期间死亡的患者的治疗前值相似。
