Biboulet P, Deschodt J, Aubas P, Vacher E, Chauvet P, D'Athis F
Department of Anesthesiology A, University Hospital, Montpellier, France.
Reg Anesth. 1993 May-Jun;18(3):170-5.
This study was designed to assess the predictability of 5 mg bupivacaine to give a T10 sensory level when injected subarachnoid in elderly patients.
Sixty-five patients aged 75 years or more, scheduled to undergo elective hip surgery, participated in the study. Patients were randomized to receive either 5 mg plain bupivacaine without epinephrine (isobaric group), or 5 mg hyperbaric bupivacaine (hyperbaric group). A 19-gauge catheter was inserted at the L3-4 interspace and threaded 4 cm cephalad in the subarachnoid space. Patients were placed in supine horizontal position and sensory level was assessed every 5 minutes over 20 minutes. Increments of 2.5 mg bupivacaine were given when sensory level did not reach T10 at the 20th minute.
After 20 minutes, the mean sensory level was T8.8 +/- 3.2 in the isobaric group and T7.2 +/- 4.3 in the hyperbaric group without significant difference. Hypotension, defined as greater than a 25% drop in mean arterial pressure, was not significantly different in the two groups: 37.5% and 42.4%, respectively. However, patients who developed hypotension were older (84.3 +/- 7.8 years) than the others (80.3 +/- 5.9 years), and cephalad spread of sensory anesthesia was higher in patients who developed a hypotension (T5.3 +/- 1.4 versus T9.5 +/- 4). In each group, sensory levels did not reach T10 in five patients after initial dose. Five had a sensory block that was too low in spite of incremental doses with the patient in the horizontal position. For the last three, an unintentional sacral placement of the catheter was proved radiologically.
The authors conclude that 5 mg bupivacaine is too high a dose in the elderly to limit the sensory blockade at T10 and avoid hypotension. In elderly patients, this dose allowed surgery to be performed, provided that the sensory level reached T10. When the initial dose only affects lumbar dermatomes, a caudal direction of the catheter must be evoked, and changing position must be preferred to incremental injections to reach thoracic levels.
本研究旨在评估老年患者蛛网膜下腔注射5mg布比卡因时达到T10感觉平面的可预测性。
65例年龄75岁及以上、计划行择期髋关节手术的患者参与本研究。患者被随机分为两组,分别接受5mg不含肾上腺素的等比重布比卡因(等比重组)或5mg重比重布比卡因(重比重组)。在L3-4椎间隙插入一根19号导管,并在蛛网膜下腔向头端置入4cm。患者取仰卧位,在20分钟内每隔5分钟评估一次感觉平面。若在第20分钟时感觉平面未达到T10,则追加2.5mg布比卡因。
20分钟后,等比重组平均感觉平面为T8.8±3.2,重比重组为T7.2±4.3,两组间无显著差异。定义为平均动脉压下降超过25%的低血压在两组中无显著差异,分别为37.5%和42.4%。然而,发生低血压的患者年龄比未发生低血压的患者大(分别为84.3±7.8岁和80.3±5.9岁),且发生低血压患者的感觉麻醉头端扩散更高(T5.3±1.4对比T9.5±4)。每组中,初始剂量后有5例患者感觉平面未达到T10。有5例患者尽管在水平位追加了剂量,但感觉阻滞仍过低。对于最后3例患者,经放射学检查证实导管意外置入骶部。
作者得出结论,对于老年患者,5mg布比卡因剂量过高,无法将感觉阻滞限制在T10并避免低血压。在老年患者中,只要感觉平面达到T10,该剂量可用于手术。当初始剂量仅影响腰部皮节时,必须考虑将导管向尾端置入,且为达到胸段平面,改变体位比追加注射更可取。