Bichler A, Daxenbichler G, Geir W
Clin Chim Acta. 1977 Jan 17;74(2):133-8. doi: 10.1016/0009-8981(77)90214-5.
Palmitic acid concentrations in amniotic fluid (AF) were determined in 135 patients with normal and pathological pregnancies between the 27th and 42nd week of gestation. There was a sharp rise in the mean palmitic acid concentration after the 34th weeks of gestation from 2.7 mug/ml to 9.9 mug/ml at term. This increase is almost identical with the rise of AF-lecithin. It was found that between 70% and 100% of AF-palmitic acid originates from lecithin. 65 patients were delivered within 24 h after amniotic fluid sampling. 7 infants of these patients developed a respiratory distress syndrome (RDS). In all cases with RDS AF-palmitic acid concentration was far below 5 mug/ml. Assuming an AF-palmitic acid concentration greater than 5 mug/ml for characterising fetal lung maturity (=no RDS), there were no false negative results, but 16% false positive results. However, the determination of AF-palmitic acid concentration seems to be a most reliable method for the assessment of fetal lung maturity.
对135例妊娠27至42周的正常及病理妊娠患者的羊水（AF）中棕榈酸浓度进行了测定。妊娠34周后，平均棕榈酸浓度从2.7微克/毫升急剧上升至足月时的9.9微克/毫升。这种增加几乎与羊水卵磷脂的增加相同。研究发现，70%至100%的羊水棕榈酸来源于卵磷脂。65例患者在羊水取样后24小时内分娩。这些患者中有7名婴儿发生了呼吸窘迫综合征（RDS）。在所有RDS病例中，羊水棕榈酸浓度远低于5微克/毫升。假设以大于5微克/毫升的羊水棕榈酸浓度来表征胎儿肺成熟（=无RDS），则没有假阴性结果，但有16%的假阳性结果。然而，测定羊水棕榈酸浓度似乎是评估胎儿肺成熟度的最可靠方法。
