Lombard E H, Mansvelt E P
Department of Haematological Pathology, University of Stellenbosch and Tygerberg Hospital, Parowvallei, Cape Province.
Tuber Lung Dis. 1993 Apr;74(2):131-5. doi: 10.1016/0962-8479(93)90041-U.
The peripheral blood and bone marrow findings in 25 patients found to have tuberculous granulomata on bone marrow examination were examined to determine whether specific haematological findings are associated with tuberculous infiltration of the bone marrow. All the patients had one abnormality or more on their full blood count. The presence of a peripheral lymphopaenia was the single factor common to all 25 patients studied. The peripheral lymphopaenia was only associated with bone marrow lymphopaenia in 14% of patients. Other findings of note were an association of peripheral monocytopaenia and absence of giant cells in the granulomata, and decreased iron stores in almost a third of the total number of patients. The relevance of the lymphopaenia, monocytopaenia and decreased iron stores are discussed and we propose that the absence of a peripheral lymphopaenia makes it very unlikely that there will be tuberculous localization in the bone marrow.
对25例经骨髓检查发现有结核性肉芽肿的患者的外周血和骨髓检查结果进行了分析，以确定是否有特定的血液学检查结果与骨髓结核浸润相关。所有患者的全血细胞计数均有一项或多项异常。外周血淋巴细胞减少是所有25例研究患者共有的单一因素。外周血淋巴细胞减少仅在14%的患者中与骨髓淋巴细胞减少相关。其他值得注意的发现是外周血单核细胞减少与肉芽肿中无巨细胞相关，以及近三分之一的患者铁储备减少。本文讨论了淋巴细胞减少、单核细胞减少和铁储备减少的相关性，并提出外周血淋巴细胞不减少时，骨髓发生结核定位的可能性极小。
