De Marinis M, Argenta G, Mele D, Carbone A, Baffigo G, Agnoli A
Department of Neurological Sciences, La Sapienza University, Rome, Italy.
Clin Auton Res. 1993 Apr;3(2):125-30. doi: 10.1007/BF01818997.
Investigation of vesico-urethral and sweating function was performed in twelve patients with classical idiopathic Parkinson's disease and ten patients with parkinsonism associated with features suggestive of more extensive involvement of the nervous system, as in the Shy-Drager syndrome. The urodynamic studies revealed detrusor hyperreflexia with reduction of maximal cystometric capacity in only one patient with Parkinson's disease (8%), but in nine patients with parkinsonism associated with other features (90%). Urethral sphincter electromyography did not indicate denervation in any patient of either group. Delayed or incomplete relaxation of the urethral sphincter during micturition was observed in seven patients with Parkinson's disease (58%) and in two patients of the other group (20%). Decreased sweating responses were found in both groups of patients when compared with control subjects. Hypohidrosis was more pronounced in parkinsonism associated with other features than in Parkinson's disease. Differences in sweating between the two sides of the body were observed in both groups of patients. Although there are differences in vesico-urethral and sweating function, they do not precisely differentiate between patients with classical Parkinson's disease and those with parkinsonism associated with features suggestive of more extensive involvement of the nervous system.
对12例典型特发性帕金森病患者和10例伴有提示神经系统更广泛受累特征的帕金森综合征患者（如Shy-Drager综合征）进行了膀胱尿道和出汗功能研究。尿动力学研究显示，仅1例帕金森病患者（8%）出现逼尿肌反射亢进且最大膀胱测压容量降低，但9例伴有其他特征的帕金森综合征患者（90%）出现该情况。两组患者的尿道括约肌肌电图均未显示去神经支配。排尿时，7例帕金森病患者（58%）和另一组的2例患者（20%）观察到尿道括约肌延迟或不完全松弛。与对照组相比，两组患者的出汗反应均降低。与帕金森病相比，伴有其他特征的帕金森综合征患者的少汗更为明显。两组患者均观察到身体两侧出汗存在差异。尽管膀胱尿道和出汗功能存在差异，但它们并不能精确区分典型帕金森病患者和伴有提示神经系统更广泛受累特征的帕金森综合征患者。
