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[全身性给予与注射到大鼠纹状体中时氟哌啶醇的效果比较]

[A comparison of the effects of haloperidol when administered systemically and injected into the striatum of rats].

作者信息

Iakimovskiĭ A F

出版信息

Eksp Klin Farmakol. 1993 Jan-Feb;56(1):11-3.

PMID:8324466
Abstract

The effects of chronic intraperitoneal (2 mg/kg) and bilaterally intrastriatal (5 micrograms) haloperidol were studied in albino male rats. Intraperitoneal injections resulted in inhibition of conditioned avoidance reflexes and catalepsy. After intrastriatal microinjections, the Parkinsonism-like status appeared along with akinesia and rigidity; that effect was recorded on day 7 of the experiment, which lasted up to the first few days of haloperidol withdrawal. The causes of distinctions between the effects of systemic and local intrastriatal haloperidol injections are discussed.

摘要

研究了慢性腹腔注射（2毫克/千克）和双侧纹状体内注射（5微克）氟哌啶醇对白化雄性大鼠的影响。腹腔注射导致条件性回避反射抑制和僵住症。纹状体内微量注射后，出现类似帕金森病的状态，伴有运动不能和强直；该效应在实验第7天出现，并持续到氟哌啶醇撤药后的头几天。讨论了全身和局部纹状体内注射氟哌啶醇效应差异的原因。

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