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[氟哌啶醇诱导的僵住症状态与被动回避条件反射的相互作用]

[The interaction of a state of haloperidol-induced catalepsy and a passive-avoidance conditioned reflex].

作者信息

Bazian A S, Getsova V N, Orlova N V

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1996 Jul-Aug;46(4):787-94.

PMID:8984818
Abstract

Injection of haloperidol (2.5 mg/kg) immediately after elaboration of the passive avoidance conditioned reflex stabilized retrieval of the conditioned reflex on the 2nd, 7th, and 14th days. Catalepsy induced by haloperidol injection was increased after the completion of passive avoidance conditioning. Conditioned reflex retrieval decreased catalepsy which was retrieved without repeated haloperidol injection. In contrast to the control animals, in the animals after conditioning the most pronounced catalepsy was observed immediately after the conditioned reflex retrieval with the following stabilization at the lower level. The auto enhancement of catalepsy retrieval was more expressed on the 14th day (as compared with the 7th day) both in the control and learned animals, but in the latter it did not depend on the testing time (in contrast to the control animals.

摘要

在建立被动回避条件反射后立即注射氟哌啶醇(2.5毫克/千克),可在第2天、第7天和第14天稳定条件反射的恢复。被动回避条件反射完成后,注射氟哌啶醇引起的僵住症有所增加。条件反射恢复可减少僵住症,且无需重复注射氟哌啶醇即可恢复。与对照动物相比,在条件反射恢复后立即观察到经条件反射处理的动物出现最明显的僵住症,随后稳定在较低水平。在第14天(与第7天相比),对照动物和经学习的动物中僵住症恢复的自我增强更为明显,但在后者中,其不依赖于测试时间(与对照动物相反)。

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