Gorodetskaia E A, Allabergenova E A, Medvedev O S
Eksp Klin Farmakol. 1993 Jan-Feb;56(1):31-3.
The response of the rat cardiovascular system to the cardiac glycoside ouabain was studied in an original model of heart failure developed on day 21 of coronary embolization with 15 microns radioactive microspheres introduced into the left ventricular cavity during ascending aortic occlusion. To examine systemic and regional hemodynamic parameters, the tracer technique with microspheres. Ouabain infused to rats with heart failure caused an increase in the index of left ventricular contractility, cardiac output, stroke volume, myocardial contractility, blood flow in most viscera and a decrease in end-diastolic pressure. The findings suggest that 21 days after coronary embolization the rats with heart failure proved more sensitive to the glycoside than did those sham-operated and thus, the presented model adequately reflects the status of the cardiovascular system when heart failure is evolving.
在一种心力衰竭的原始模型中，研究了大鼠心血管系统对强心苷哇巴因的反应。该模型是在冠状动脉栓塞第21天建立的，在升主动脉闭塞期间，将15微米的放射性微球注入左心室腔。为了检查全身和局部血流动力学参数，采用了微球示踪技术。给心力衰竭大鼠输注哇巴因可使左心室收缩性指数、心输出量、每搏量、心肌收缩性、大多数内脏的血流量增加，舒张末期压力降低。研究结果表明，冠状动脉栓塞21天后，心力衰竭大鼠对该苷的敏感性高于假手术大鼠，因此，所提出的模型充分反映了心力衰竭进展时心血管系统的状态。
